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首页> 外文期刊>Acta biomaterialia >Thermoresponsive magnetic composite nanomaterials for multimodal cancer therapy.
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Thermoresponsive magnetic composite nanomaterials for multimodal cancer therapy.

机译：热响应磁性复合纳米材料用于多式联癌疗法。

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The synthesis, characterization and property evaluation of drug-loaded polymer-coated magnetic nanoparticles (MNPs) relevant to multimodal cancer therapy has been studied. The hyperthermia and controlled drug release characteristics of these particles was examined. Magnetite (Fe(3)O(4))-poly-n-(isopropylacrylamide) (PNIPAM) composite MNPs were synthesized in a core-shell morphology by dispersion polymerization of n-(isopropylacrylamide) chains in the presence of a magnetite ferrofluid. These core-shell composite particles, with a core diameter of approximately 13nm, were loaded with the anti-cancer drug doxorubicin (dox), and the resulting composite nanoparticles (CNPs) exhibit thermoresponsive properties. The magnetic properties of the composite particles are close to those of the uncoated magnetic particles. In an alternating magnetic field (AMF), composite particles loaded with 4.15 wt.% dox exhibit excellent heating properties as well as simultaneous drug release. Drug release testing confirmed that release was much higher above the lower critical solution temperature (LCST) of the CNP, with a release of up to 78.1% of bound dox in 29h. Controlled drug release testing of the particles reveals that the thermoresponsive property can act as an on/off switch by blocking drug release below the LCST. Our work suggests that these dox-loaded polymer-coated MNPs show excellent in vitro hyperthermia and drug release behavior, with the ability to release drugs in the presence of AMF, and the potential to act as agents for combined targeting, hyperthermia and controlled drug release treatment of cancer.
机译：研究了与多模式癌疗法相关的药物负载聚合物涂覆的磁性纳米粒子（MNP）的合成，表征和性质评价。检查这些颗粒的热疗和受控药物释放特征。磁铁矿（Fe（3）O（4）） - 通过在磁铁矿铁物流体存在下通过N-（异丙基丙烯酰胺）链的分散聚合，在核 - 壳形态中合成聚丙烯酰胺（异丙基丙烯酰胺）（PNIPAM）复合MNP。这些核 - 壳复合颗粒具有约13nm的核心直径，加载抗癌药物Doxorubicin（DOX），并得到的复合纳米颗粒（CNP）表现出热敏性质。复合颗粒的磁性靠近未涂覆的磁性颗粒的磁性。在交替的磁场（AMF）中，加载4.15重量％的复合颗粒。％DOX表现出优异的加热性能以及同时药物释放。药物释放试验证实，CNP的释放高于临界溶液温度（LCST）的释放远高得多，释放在29h中的粘合多达78.1％。对颗粒的受控药物释放试验表明，热响应性能可以通过阻塞LCST下方的药物释放作为开/关开关。我们的作品表明，这些负载量的聚合物涂层的MNP具有优异的体外热疗和药物释放行为，具有释放药物在AMF存在下的能力，以及作为组合靶向，热疗和受控药物释放的药物的可能性治疗癌症。

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