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首页> 外文期刊>Acta biomaterialia >Urethra-inspired biomimetic scaffold: A therapeutic strategy to promote angiogenesis for urethral regeneration in a rabbit model
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Urethra-inspired biomimetic scaffold: A therapeutic strategy to promote angiogenesis for urethral regeneration in a rabbit model

机译：尿道启发仿生脚手架：促进尿道模型中尿道再生血管生成的治疗策略

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摘要

Limited angiogenesis and epithelialization make urethral regeneration using conventional tissue-engineered grafts a great challenge. Consequently, inspired from the native urethra, bacterial cellulose (BC) and bladder acellular matrix (BAM) were combined to design a three dimensional (3D) biomimetic scaffold. The developed BC/BAM scaffold was engineered for accelerating urethral regeneration by enhancing angiogenesis and epithelialization. The BC/BAM scaffold reveals the closest mimic of native urethra in terms of the 3D porous nanofibrous structure and component including collagen, glycosaminoglycans, and intrinsic vascular endothelial growth factor (VEGF). In vitro studies showed that the bioinspired BC/BAM scaffold promoted in vitro angiogenesis by facilitating human umbilical vein endothelial cells (HUVECs) growth, expression of endothelial function related proteins and capillary-like tube formation. Effect of the BC/BAM scaffold on angiogenesis and epithelialization was studied by its implantation in a rabbit urethral defect model for 1 and 3 months. Results demonstrated that the improved blood vessels formation in the urethra-inspired BC/BAM scaffold significantly promoted epithelialization and accelerated urethral regeneration. The urethra-inspired BC/BAM scaffold provides us a new design approach to construct grafts for urethral regeneration.
机译：有限的血管生成和上皮化使用常规组织工程移植的尿道再生产生巨大的挑战。因此，从天然尿道，细菌纤维素（BC）和膀胱细胞基质（BAM）的启发以设计三维（3D）仿真支架。通过增强血管生成和上皮化，设计了开发的BC / BAM支架以加速尿道再生。在3D多孔纳米纤维结构和组分中，BC / BAM支架揭示了本地尿道的最接近的模仿，包括胶原蛋白，糖胺聚糖和内在血管内皮生长因子（VEGF）。体外研究表明，通过促进人的脐静脉内皮细胞（HUVECS）生长，内皮函数相关蛋白质和毛细管状管形成的表达，Bioinspired BC / BAM支架促进了体外血管生成。通过其植入兔尿道缺陷模型1和3个月，研究了BC / BAM支架对血管生成和上皮细胞化的影响。结果表明，尿道启发的BC / BAM支架中的改善血管形成显着促进了上皮性和加速尿道再生。尿道启发的BC / BAM脚手架为我们提供了一种构建尿道再生移植物的新设计方法。

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  • 来源
    《Acta biomaterialia》 |2020年第2020期|共12页
  • 作者

    Wang Baoxiu; Lv Xiangguo; Li Zhe; Zhang Minghao; Yao Jingjing; Sheng Nan; Lu Mujun; Wang Huaping; Chen Shiyan;

  • 作者单位

    Donghua Univ Coll Mat Sci &

    Engn State Key Lab Modificat Chem Fibers &

    Polymer Mat Shanghai;

    Shanghai Jiao Tong Univ Sch Med Shanghai Renji Hosp Dept Urol &

    Androl Shanghai 200001 Peoples;

    Jiaxing Univ Coll Mat &

    Text Engn Hangzhou 314001 Zhejiang Peoples R China;

    Donghua Univ Coll Mat Sci &

    Engn State Key Lab Modificat Chem Fibers &

    Polymer Mat Shanghai;

    Donghua Univ Coll Mat Sci &

    Engn State Key Lab Modificat Chem Fibers &

    Polymer Mat Shanghai;

    Donghua Univ Coll Mat Sci &

    Engn State Key Lab Modificat Chem Fibers &

    Polymer Mat Shanghai;

    Shanghai Jiao Tong Univ Sch Med Shanghai Renji Hosp Dept Urol &

    Androl Shanghai 200001 Peoples;

    Donghua Univ Coll Mat Sci &

    Engn State Key Lab Modificat Chem Fibers &

    Polymer Mat Shanghai;

    Donghua Univ Coll Mat Sci &

    Engn State Key Lab Modificat Chem Fibers &

    Polymer Mat Shanghai;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 普通生物学;
  • 关键词

    Bioinspired; Angiogenesis; Bacterial cellulose; Bladder acellular matrix; Urethral repair;

    机译：Bioinspired;血管生成;细菌纤维素;膀胱细胞基质;尿道修复;

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