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首页> 外文期刊>Acta biomaterialia >The dual character of exosomes in osteoarthritis: Antagonists and therapeutic agents
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The dual character of exosomes in osteoarthritis: Antagonists and therapeutic agents

机译：骨关节炎外泌体的双重特征：拮抗剂和治疗剂

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摘要

Exosomes have gained increasing attention as they participate in cell cross-talk in pathological environments and are functional paracrine factors of therapeutic stem cells. Osteoarthritis (OA) is a common age-related degenerative joint disease, leading to a debilitating lifestyle for sufferers. However, currently no drugs on the market promote cartilage repair, and the patients usually have to undergo arthroplasty in the late stage of OA. Although significant progress has been made in the development of stem cells for the treatment of OA and cartilage injury, problems like immune rejection remain. Recently, increasing evidence has demonstrated that exosomes from the joint microenvironment ("negative" exosomes) could play vital and complicated roles in the progression of OA. Moreover, exosomes from therapeutic cells ("therapeutic" exosomes) have also shown enormous potential for OA therapy/cartilage repair. Here, we first discuss the definition and biological background of exosomes. Then, we critically examine the roles of the "negative" exosomes in OA-affected joint. Then, we will cover the potential of the "therapeutic" exosomes for OA therapy/cartilage repair. Next, the recent progress of tissue engineering with exosomes, especially for OA therapy/cartilage repair, will also be discussed. Finally, the limitations and opportunities of exosome-based OA therapy will be outlined.
机译：当他们参与病理环境中的细胞交叉谈话时，外泌体越来越受到关注，并且是治疗干细胞的功能性旁静脉因子。骨关节炎（OA）是一种常见的年龄相关的退行性关节疾病，导致患有患者的衰弱生活方式。但是，目前没有对市场的药物促进软骨修复，并且患者通常必须在OA的后期进行关节造身术。虽然在干细胞的发展中取得了显着进展，但治疗OA和软骨损伤，仍然存在免疫排斥等问题。最近，越来越多的证据表明，来自关节微环境的外泌体（“阴性”外虫物质）可以在OA的进展中起着至关重要的作用。此外，来自治疗细胞的外泌体（“治疗性”外来体）也表明OA治疗/软骨修复的巨大潜力。在这里，我们首先讨论外来体的定义和生物学背景。然后，我们彻底检查受影响的关节中的“阴性”外来体的作用。然后，我们将涵盖OA疗法/软骨修复的“治疗性”外索体的潜力。接下来，还将讨论与外来组织工程的最近进展，特别是对于OA治疗/软骨修复。最后，将概述基于外科的OA治疗的局限性和机会。

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