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首页> 外文期刊>Acta biomaterialia >In vivo analysis of a first-in-class tri-alkyl norspermidine-biaryl antibiotic in an active release coating to reduce the risk of implant-related infection
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In vivo analysis of a first-in-class tri-alkyl norspermidine-biaryl antibiotic in an active release coating to reduce the risk of implant-related infection

机译：在活性释放涂层中对一类级三烷基芳酰基氨基氨基 - 丙酰胺 - 抗生素的体内分析，以降低植入物相关感染的风险

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摘要

Prosthetic joint infection (PJI) is a well-known and persisting problem. Active release coatings have promise to provide early protection to an implant by eradicating small colony biofilm contaminants or planktonic bacteria that can form biofilm. Traditional antibiotics can be limited as active release agents in that they have limited effect against biofilms and develop resistance at sub-lethal concentrations. A unique first-in-class compound (CZ-01127) was assessed as the active release agent in a silicone (Si)-based coating to prevent PJI in a sheep model of joint space infection. Titanium (Ti) plugs contained a porous coated Ti (PCTi) region and polymer-coated region. Plugs were implanted into a femoral condyle of sheep to assess the effect of the Si polymer on cancellous bone ingrowth, the effect of CZ-01127 on bone ingrowth, and the ability of CZ-01127 to prevent PJl. Microbiological results showed that CZ-01127 was able to eradicate bacteria in the local region of the implanted plugs. Data further showed that Si did not adversely affect bone ingrowth. However, bacteria that reached the joint space (synovium) were not fully eradicated. Outcomes suggested that the CZ-01127 coating provided local protection to the implant system in a challenging model, the design of which could be beneficial for testing future antimicrobial therapies for PJI.
机译：假肢关节感染（PJI）是一个众所周知和持久的问题。主动释放涂层承诺通过消除可以形成生物膜的小菌落生物膜污染物或浮游细菌来为植入物提供早期保护。传统的抗生素可以限制为活性释放剂，因为它们对生物膜的影响有限，并在亚致死浓度下产生抗性。在基于硅氧烷（Si）的涂层中，评估唯一的一类级化合物（CZ-01127）作为基于硅氧烷（Si）的活性脱模剂，以防止PJI在关节空间感染的绵羊模型中。钛（Ti）塞含有多孔涂层Ti（PCTI）区和聚合物涂层区域。将塞子植入绵羊的股髁上，以评估Si聚合物对松质骨产生的影响，CZ-01127对骨骼产生的影响，以及CZ-01127预防PJL的能力。微生物学结果表明，CZ-01127能够在植入塞的局部区域中根除细菌。数据进一步表明Si不会对骨骼产生不利影响。然而，没有完全消除达到关节空间（Synovium）的细菌。结果表明，CZ-01127涂层在一个具有挑战性的模型中为植入系统提供了局部保护，其设计可以有利于测试PJI的未来抗微生物疗法。

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