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首页> 外文期刊>Acta biomaterialia >Injectable Click Chemistry-based Bioadhesives for Accelerated Wound Closure
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Injectable Click Chemistry-based Bioadhesives for Accelerated Wound Closure

机译：可注射点击基于化学的生物粘合剂，用于加速伤口闭合

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摘要

Tissue adhesives play a vital role in surgical processes as a substitute for sutures in wound closure. However, several existing tissue adhesives suffer from cell toxicity, weak tissue-adhesive strength, and high cost. In this study, by taking advantage of the fast and specific inverse-demand Diels-Alder cycloaddition reaction, a series of bioadhesives were produced by employing copper-free click chemistry pair trans-cyclooctene (TCO) /tetrazine (Tz) in chitosan. The gelation time of the bioadhesives can be optimized to be less than 2 minutes, which meets the need for surgical wound closure in practice. By adding 4-arm polyethylene glycol propionaldehyde (PEG-PALD) as a co-crosslinker, the adhesive strength of the bioad-hesives was optimized to be 2.3 times higher than that of the conventional fibrin glue. Moreover, by adjusting the amount of the co-crosslinker, the swelling ratio and pore size of the chitosan bioadhesives can be tuned to fit the need of drug encapsulation and cell seeding. The chitosan bioadhesives possess no significant in vitro cytotoxicity. Using a mice skin incision wound model, we found that the chitosan bioadhesives were able to close the wound faster and promote wound healing process than the fibrin glue. In conclusion, our results support that the innovative click-chemistry based bioadhesives have been developed with improved physical and biological properties for surgical wound closures.
机译：组织粘合剂在手术过程中发挥着至关重要的作用，作为伤口闭合的缝合线的替代品。然而，几种现有的组织粘合剂患有细胞毒性，弱组织粘合强度和高成本。在这项研究中，通过利用快速和特异性的逆水剂Diels-Alder环加成反应，通过在壳聚糖中使用无铜咔哒化化学对转速（TCO）/四嗪（TZ）来制备一系列生物粘附。生物粘合剂的凝胶化时间可以优化为小于2分钟，这符合在实践中需要手术伤口闭合的需求。通过将4臂聚乙二醇丙醛（PEG-PALD）作为共交交联剂，优化生物焊接的粘合强度为常规纤维蛋白胶水的2.3倍。此外，通过调节共交联剂的量，可以调整壳聚糖生物粘合剂的溶胀比和孔径以适应药物包封和细胞播种的需要。壳聚糖生物粘附性在体外细胞毒性没有显着性。使用小鼠皮肤切口伤口模型，我们发现壳聚糖生物粘附能够更快地关闭伤口，促进伤口愈合过程比纤维蛋白胶。总之，我们的成果支持，已开发出创新的基于Chemictry基础的生物粘合剂，其具有改善的外科伤口闭合的物理和生物学性质。

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