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首页> 外文期刊>Acta biomaterialia >Self-assembling and auto-crosslinkable hyaluronic acid hydrogels with a fibrillar structure.
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Self-assembling and auto-crosslinkable hyaluronic acid hydrogels with a fibrillar structure.

机译：具有纤维结构的自组装和自交联的透明质酸水凝胶。

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摘要

A hyaluronic acid derivative bearing pendant L-benzoyl-cysteine portions (with a derivatization degree equal to 10 mol.%) was synthesized by linking N,N'-dibenzoyl-L-cystine to the polysaccharide and then reducing its disulfide bridge to thiol groups. The formation of pi-pi stacking interactions between the benzoyl moieties was studied by fluorescence spectroscopy as a function of polymer concentration and oxidation time. The efficiency of oxidation of thiol groups to disulfide bridges occurring in phosphate buffer pH 7.4, was determined by colorimetric assays. The hydrogel formed by means of oxidative crosslinking has shown the presence of fibrillar aggregates as detected by light and scanning electron microscopy. Human derm fibroblasts were encapsulated into hydrogel-forming solution, and their ability to proliferate was tested during 3 days of culture.
机译：通过将N，N'-二苯甲酰基-1-胱氨酸连接到多糖，通过将N，N'-二苯甲酰基-L-胱氨酸连接到多糖，合成透明质酸衍生物轴承悬垂L-苯甲酰基 - 半胱氨酸部分（具有等于10摩尔％的衍生体积），然后将其二硫化物桥还原为硫醇基团合成 。 通过荧光光谱法根据聚合物浓度和氧化时间的函数研究苯甲酰基之间的PI-PI堆叠相互作用。 通过比色测定法测定在磷酸盐缓冲液pH7.4中发生的二硫化物桥的硫化物桥的效率。 通过氧化交联形成的水凝胶已经示出了由光和扫描电子显微镜检测的纤维状聚集体的存在。 将人的DERM成纤维细胞包封成水凝胶形成溶液，在3天培养期间测试它们的增殖能力。

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