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首页> 外文期刊>Acta biomaterialia >Block copolymers for the rational design of self-forming postsurgical adhesion barriers.
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Block copolymers for the rational design of self-forming postsurgical adhesion barriers.

机译：嵌段共聚物，用于自成形后勤粘附屏障的合理设计。

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Post-surgical adhesions, abnormal fibrous linkages between adjacent tissue surfaces, represent one of the most common and significant complications facing surgical recovery today. Physical barriers and gels have been the most successful at limiting their formation, yet are not effective in cases where the pro-adhesive site is either unknown or difficult to reach (e.g. during laparoscopic surgery). In this work, poly(methacrylic acid-co-t-butylmethacrylate)-b-poly(ethylene glycol (M(N) = 1000) methacrylate) diblock and statistical copolymers were synthesized as a platform for designing self-forming adhesion barriers, which can attach to exposed pro-adhesive sites through binding with the positively charged extracellular matrix, basement membrane proteins and deposited fibrin. An experimental model based upon a quartz crystal microbalance with dissipation was developed to test the diblock copolymers ability (i) to adsorb to an amine-terminated self-assembled monolayer, and (ii) to inhibit subsequent protein adsorption. These results were also confirmed using an in vitro cell attachment model. As the mole fraction of methacrylic acid content increased, polymer adsorption increased. All synthesized diblock copolymers investigated provided high resistance to protein adsorption, with blockade ranging from 55% to 81%. Except for the uncharged control polymers, the ability of these materials to resist cellular attachment showed similar trends, with the suppression of attachment approaching 75%. Energy dissipation analysis and variable-angle spectroscopic ellipsometry revealed two competing adsorption mechanisms depending on the molecular properties of the polymer.
机译：外科后粘连，相邻组织表面之间的异常纤维键，代表了今天外科恢复面临的最常见和显着的并发症之一。在限制其形成时，物理障碍和凝胶是最成功的，但在亲粘性部位未知或难以到达的情况下，尚未有效（例如，在腹腔镜手术期间）。在这项工作中，聚（甲基丙烯酸 - 二叔丁基丙烯酸甲基丙烯酸甲酯）-B-聚（乙二醇（N）= 1000）甲基丙烯酸酯）二嵌段和统计共聚物被合成为设计自成形粘附屏障的平台，可以通过与带正电荷的细胞外基质，基底膜蛋白和沉积的纤维蛋白结合来连接到暴露的脱粘部位。开发了基于石英晶体微稳定的实验模型，以测试二嵌段共聚物能力（I）吸附到胺封端的自组装单层，（II）以抑制随后的蛋白质吸附。还使用体外细胞附着模型确认这些结果。随着甲基丙烯酸含量的摩尔分数增加，聚合物吸附增加。所有合成的二嵌段共聚物研究提供了高抗蛋白质吸附的耐受性，阻滞从55％达81％。除了不带电的控制聚合物外，这些材料抵抗蜂窝连接的能力显示出类似的趋势，抑制了75％的附着。能量耗散分析和可变角度光谱椭圆形测定法根据聚合物的分子特性显示出两种竞争吸附机制。

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