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首页> 外文期刊>Acta biomaterialia >Salicylic acid-releasing polyurethane acrylate polymers as anti-biofilm urological catheter coatings
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Salicylic acid-releasing polyurethane acrylate polymers as anti-biofilm urological catheter coatings

机译：水杨酸释放聚氨酯丙烯酸酯聚合物作为抗生物膜泌尿泌尿导管涂层

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摘要

Biofilm-associated infections are a major complication of implanted and indwelling medical devices like urological and venous catheters. They commonly persist even in the presence of an oral or intravenous antibiotic regimen, often resulting in chronic illness. We have developed a new approach to inhibiting biofilm growth on synthetic materials through controlled release of salicylic acid from a polymeric coating. Herein we report the synthesis and testing of a ultraviolet-cured polyurethane acrylate polymer composed, in part, of salicyl acrylate, which hydrolyzes upon exposure to aqueous conditions, releasing salicylic acid while leaving the polymer backbone intact. The salicylic acid release rate was tuned by adjusting the polymer composition. Anti-biofilm performance of the coatings was assessed under several biofilm forming conditions using a novel combination of the MBEC Assay? biofilm multi-peg growth system and bioluminescence monitoring for live cell quantification. Films of the salicylic acid-releasing polymers were found to inhibit biofilm formation, as shown by bioluminescent and GFP reporter strains of Pseudomonas aeruginosa and Escherichia coli. Urinary catheters coated on their inner lumens with the salicylic acid-releasing polymer significantly reduced biofilm formation by E. coli for up to 5 days under conditions that simulated physiological urine flow.
机译：生物膜相关的感染是泌尿和留置医疗器械如泌尿外和静脉导管的主要复杂性。甚至在口服或静脉抗生素方案存在下常常持续存在，通常导致慢性疾病。我们通过从聚合物涂层控制释放水杨酸释放来抑制合成材料的生物膜生长的新方法。在本文中，我们报告了紫外线固化的聚氨酯丙烯酸酯聚合物的合成和测试，其中组成的丙烯酸水杨酸盐酯，其在暴露于含水条件下水解，释放水杨酸，同时使聚合物主链完好无损。通过调节聚合物组合物来调节水杨酸释放速率。使用MBEC测定的新组合在几种生物膜形成条件下评估涂层的抗生物膜性能？生物膜多PEG生长系统和活细胞定量的生物发光监测。发现水杨酸释放聚合物的薄膜抑制生物膜形成，如Biodomonas Aeruginosa和大肠杆菌的生物发光和GFP报告菌株所示。在其内腔上涂有水杨酸释放聚合物的尿导管显着降低了大肠杆菌在模拟生理尿液流动的条件下形成了5天的生物膜形成。

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  • 来源
    《Acta biomaterialia》 |2012年第5期|共12页
  • 作者

    NowatzkiP.J.; KoepselR.R.; StoodleyP.; MinK.; HarperA.; MurataH.; DonfackJ.; HortelanoE.R.; EhrlichG.D.; RussellA.J.;

  • 作者单位

    Bayer MaterialScience LLC 100 Bayer Rd. Pittsburgh PA United States;

    McGowan Institute for Regenerative Medicine Department of Surgery University of Pittsburgh 450;

    National Centre for Advanced Tribology at Southampton (NCATS) Faculty of Engineering and the;

    Bayer MaterialScience LLC 100 Bayer Rd. Pittsburgh PA United States;

    Center for Genomic Sciences Allegheny-Singer Research Institute Allegheny General Hospital;

    McGowan Institute for Regenerative Medicine Department of Surgery University of Pittsburgh 450;

    Center for Genomic Sciences Allegheny-Singer Research Institute Allegheny General Hospital;

    Bayer MaterialScience LLC 100 Bayer Rd. Pittsburgh PA United States;

    Center for Genomic Sciences Allegheny-Singer Research Institute Allegheny General Hospital;

    McGowan Institute for Regenerative Medicine Department of Surgery University of Pittsburgh 450;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 普通生物学;
  • 关键词

    Biofilm; Controlled release; Polyurethane; Salicylic acid;

    机译：生物膜;控释;聚氨酯;水杨酸;

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