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Calcium phosphate cements for bone substitution: Chemistry, handling and mechanical properties

机译:骨替代磷酸钙水泥:化学,处理和机械性能

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摘要

Since their initial formulation in the 1980s, calcium phosphate cements (CPCs) have been increasingly used as bone substitutes. This article provides an overview on the chemistry, kinetics of setting and handling properties (setting time, cohesion and injectability) of CPCs for bone substitution, with a focus on their mechanical properties. Many processing parameters, such as particle size, composition of cement reactants and additives, can be adjusted to control the setting process of CPCs, concomitantly influencing their handling and mechanical performance. Moreover, this review shows that, although the mechanical strength of CPCs is generally low, it is not a critical issue for their application for bone repair - an observation not often realized by researchers and clinicians. CPCs with compressive strengths comparable to those of cortical bones can be produced through densification and/or homogenization of the cement matrix. The real limitation for CPCs appears to be their low fracture toughness and poor mechanical reliability (Weibull modulus), which have so far been only rarely studied.
机译:自20世纪80年代初始制剂以来,磷酸钙水泥(CPC)越来越多地用作骨替代品。本文概述了CPC用于骨替代的CPC的化学,设置和处理性能(设定时间,凝聚力和可注射性)的概述,重点是它们的机械性能。可以调节许多处理参数,例如粒度,水泥反应物和添加剂的组成,以控制CPC的设定过程,同时影响其处理和机械性能。此外,该综述表明,尽管CPC的机械强度通常很低,但它们对骨骼修复的应用不是一个关键问题 - 这是研究人员和临床医生通常实现的观察。具有与皮质骨骼的压缩强度相当的CPC可以通过致密化和/或水泥基质的均化产生。 CPC的实际限制似乎是它们的低断裂韧性和差的机械可靠性(Weibull模量),这是迄今为止只有很少研究。

著录项

  • 来源
    《Acta biomaterialia》 |2014年第3期|共15页
  • 作者单位

    Université de Nantes INSERM UMRS 791 Laboratoire d'Ingénierie Ostéo-Articulaire et Dentaire 1;

    Université de Nantes INSERM UMRS 791 Laboratoire d'Ingénierie Ostéo-Articulaire et Dentaire 1;

    Université de Nantes INSERM UMRS 791 Laboratoire d'Ingénierie Ostéo-Articulaire et Dentaire 1;

    Université de Nantes Polytech Nantes Institut des Matériaux Jean Rouxel Rue Christian Pauc;

    Université de Nantes INSERM UMRS 791 Laboratoire d'Ingénierie Ostéo-Articulaire et Dentaire 1;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 普通生物学;
  • 关键词

    Bone void fillers; Calcium phosphate cements; Mechanical properties; Porosity;

    机译:骨吸填料;磷酸钙水泥;机械性能;孔隙度;

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