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首页> 外文期刊>Acta biomaterialia >Tunable drug-loading capability of chitosan hydrogels with varied network architectures.
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Tunable drug-loading capability of chitosan hydrogels with varied network architectures.

机译：不同网络架构的壳聚糖水凝胶的可调谐药物装载能力。

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Advanced bioactive systems with defined macroscopic properties and spatio-temporal sequestration of extracellular biomacromolecules are highly desirable for next generation therapeutics. Here, chitosan (CT) hydrogels were prepared with neutral or negatively charged cross-linkers in order to promote selective electrostatic complexation with charged drugs. CT was functionalized with varied dicarboxylic acids, such as tartaric acid, poly(ethylene glycol) bis(carboxymethyl) ether, 1,4-phenylenediacetic acid and 5-sulfoisophthalic acid monosodium salt (PhS), whereby PhS was hypothesized to act as a simple mimetic of heparin. Attenuated total reflectance Fourier transform infrared spectroscopy showed the presence of CO amide I, N-H amide II and CO ester bands, providing evidence of covalent network formation. The cross-linker content was reversely quantified by proton nuclear magnetic resonance on partially degraded network oligomers, so that 18 mol.% PhS was exemplarily determined. Swellability (SR: 299 ± 65-1054 ± 121 wt.%), compressibility (E: 2.1 ± 0.9-9.2 ± 2.3 kPa), material morphology and drug-loading capability were successfully adjusted based on the selected network architecture. Here, hydrogel incubation with model drugs of varied electrostatic charge, i.e. allura red (AR, doubly negatively charged), methyl orange (MO, negatively charged) or methylene blue (MB, positively charged), resulted in direct hydrogel-dye electrostatic complexation. Importantly, the cationic compound, MB, showed different incorporation behaviours, depending on the electrostatic character of the selected cross-linker. In light of this tunable drug-loading capability, these CT hydrogels would be highly attractive as drug reservoirs towards e.g. the fabrication of tissue models in vitro.
机译：具有定义的宏观性质和外壳生物致杀菌性的高级生物活性系统对于下一代治疗剂非常理想。这里，用中性或带负电的交联剂制备壳聚糖（CT）水凝胶，以促进用带电药物的选择性静电络合。 CT用不同的二羧酸官能化，例如酒石酸，聚（乙二醇）双（羧甲基）醚，1,4-苯二酰胺酸和5-磺基苯二甲酸单钠盐（pHS），其中pHS被假设以充当简单肝素的模仿。减弱的总反射率傅里叶变换红外光谱显示出CO酰胺I，N-H酰胺II和CO酯带的存在，提供了共价网络形成的证据。通过质子核磁共振在部分降解的网络低聚物上反向定量交联剂含量，使得18摩尔％的pHS示例性测定。可溶胀性（SR：299±65-1054±121重量％），基于所选择的网络架构成功调整压缩性（E：2.1±0.9-9.2±2.3 kPa），材料形态和药物加载能力。这里，水凝胶与不同静电电荷的模型药物孵育，即血浆红色（Ar，双负电荷），甲基橙（Mo，带负电）或亚甲基蓝（MB，带正电荷）导致直接水凝胶染料静电络合。重要的是，阳离子化合物MB显示不同的掺入行为，这取决于所选择的交联剂的静电特征。鉴于这种可调节的药物负载能力，这些CT水凝胶将与玻璃储存器高度吸引力，例如朝向例如毒品储存器。体外组织模型的制造。

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