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首页> 外文期刊>Acta biomaterialia >(Photo-)crosslinkable gelatin derivatives for biofabrication applications
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(Photo-)crosslinkable gelatin derivatives for biofabrication applications

机译：（Photo-）可交联的明胶衍生物用于生物破坏应用

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摘要

Over the recent decades gelatin has proven to be very suitable as an extracellular matrix mimic for bio-fabrication and tissue engineering applications. However, gelatin is prone to dissolution at typical cell culture conditions and is therefore often chemically modified to introduce (photo-)crosslinkable functionalities. These modifications allow to tune the material properties of gelatin, making it suitable for a wide range of biofabrication techniques both as a bioink and as a biomaterial ink (component). The present review provides a non-exhaustive overview of the different reported gelatin modification strategies to yield crosslinkable materials that can be used to form hydrogels suitable for biofabrication applications. The different crosslinking chemistries are discussed and classified according to their mechanism including chain-growth and step-growth polymerization. The step-growth polymerization mechanisms are further classified based on the specific chemistry including different (photo-)click chemistries and reversible systems. The benefits and drawbacks of each chemistry are also briefly discussed. Furthermore, focus is placed on different biofabrication strategies using either inkjet, deposition or light-based additive manufacturing techniques, and the applications of the obtained 3D constructs.
机译：在近几十年上，明胶已被证明是一种非常适合作为生物制造和组织工程应用的细胞外基质。然而，明胶易于在典型的细胞培养条件下溶解，因此通常化学修饰以引入（光学 - ）可交联的功能。这些修饰允许调整明胶的材料性质，使其适用于各种生物制衡技术，无论是生物链和生物材料油墨（组分）。本综述提供了不同报道的明胶改性策略的非详尽概述，以产生可用于形成适合于生物破旧应用的水凝胶的可交联材料。根据它们的机制讨论和分类不同的交联化学品，包括链生长和步进生长聚合。基于包括不同（Photo-）的特定化学物质，进一步分类步骤生长聚合机制，包括不同（Photo-）咔哒化学和可逆系统。还简要讨论了每个化学的益处和缺点。此外，使用喷墨，沉积或轻基的添加剂制造技术和所获得的3D构建体的应用，将重点放在不同的生物制作策略上。

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