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首页> 外文期刊>Acta biomaterialia >Peptide science: A 'rule model' for new generations of peptidomimetics
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Peptide science: A 'rule model' for new generations of peptidomimetics

机译：肽科学：新一代肽模拟物的“规则模型”

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Peptides have been heavily investigated for their biocompatible and bioactive properties. Though a wide array of functionalities can be introduced by varying the amino acid sequence or by structural constraints, properties such as proteolytic stability, catalytic activity, and phase behavior in solution are difficult or impossible to impart upon naturally occurring alpha-L-peptides. To this end, sequence-controlled peptidomimetics exhibit new folds, morphologies, and chemical modifications that create new structures and functions. The study of these new classes of polymers, especially alpha-peptoids, has been highly influenced by the analysis, computational, and design techniques developed for peptides. This review examines techniques to determine primary, secondary, and tertiary structure of peptides, and how they have been adapted to investigate peptoid structure. Computational models developed for peptides have been modified to predict the morphologies of peptoids and have increased in accuracy in recent years. The combination of in vitro and in silico techniques have led to secondary and tertiary structure design principles that mirror those for peptides. We then examine several important developments in peptoid applications inspired by peptides such as pharmaceuticals, catalysis, and protein-binding. A brief survey of alternative backbone structures and research investigating these peptidomimetics shows how the advancement of peptide and peptoid science has influenced the growth of numerous fields of study. As peptide, peptoid, and other peptidomimetic studies continue to advance, we will expect to see higher throughput structural analyses, greater computational accuracy and functionality, and wider application space that can improve human health, solve environmental challenges, and meet industrial needs.
机译：肽已经严重研究了它们的生物相容性和生物活性性质。尽管可以通过改变氨基酸序列或通过结构约束来引入各种功能，但诸如溶液中的蛋白水解稳定性，催化活性和相行为的性质是难以或不可能赋予天然存在的α-L肽的特性。为此，序列控制的肽模拟物表现出新的褶皱，形态和化学修饰，从而产生新的结构和功能。对这些新类别的聚合物，尤其是α-肽的研究已经受到对肽开发的分析，计算和设计技术的影响。该综述检测测定肽的初级，次级和三级结构的技术，以及它们如何调整拟肽结构。已经修饰了用于肽开发的计算模型以预测拟肽的形态，并且近年来提高了准确性。体外和硅技术的组合导致了镜像肽的二级和三级结构设计原理。然后，我们在受药物，催化和蛋白质结合如药物，催化剂如药物，肽和蛋白质结合的影响下，检查拟拟肽应用的几个重要发展。简要介绍替代骨干结构和研究调查这些肽模拟物展示了肽和拟肽科学的进步如何影响众多研究领域的增长。作为肽，拟肽和其他肽模拟研究继续前进，我们将期望看到更高的吞吐量结构分析，更大的计算准确性和功能，以及可以改善人类健康，解决环境挑战的更广泛的应用空间，并满足工业需求。

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