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首页> 外文期刊>Acta biomaterialia >The interaction of cells and bacteria with surfaces structured at the nanometre scale.
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The interaction of cells and bacteria with surfaces structured at the nanometre scale.

机译：细胞和细菌与纳米级构造的表面的相互作用。

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The current development of nanobiotechnologies requires a better understanding of cell-surface interactions on the nanometre scale. Recently, advances in nanoscale patterning and detection have allowed the fabrication of appropriate substrates and the study of cell-substrate interactions. In this review we discuss the methods currently available for nanoscale patterning and their merits, as well as techniques for controlling the surface chemistry of materials at the nanoscale without changing the nanotopography and the possibility of truly characterizing the surface chemistry at the nanoscale. We then discuss the current knowledge of how a cell can interact with a substrate at the nanoscale and the effect of size, morphology, organization and separation of nanofeatures on cell response. Moreover, cell-substrate interactions are mediated by the presence of proteins adsorbed from biological fluids on the substrate. Many questions remain on the effect of nanotopography on protein adsorption. We review papers related to this point. As all these parameters have an influence on cell response, it is important to develop specific studies to point out their relative influence, as well as the biological mechanisms underlying cell responses to nanotopography. This will be the basis for future research in this field. An important topic in tissue engineering is the effect of nanoscale topography on bacteria, since cells have to compete with bacteria in many environments. The limited current knowledge of this topic is also discussed in the light of using topography to encourage cell adhesion while limiting bacterial adhesion. We also discuss current and prospective applications of cell-surface interactions on the nanoscale. Finally, based on questions raised previously that remain to be solved in the field, we propose future directions of research in materials science to help elucidate the relative influence of the physical and chemical aspects of nanotopography on bacteria and cell response with the aim of contributing to the development of nanobiotechnologies.
机译：目前纳米能力的发展需要更好地理解纳米级的细胞表面相互作用。最近，纳米级图案化和检测的进展使得允许制造适当的基材和细胞基底相互作用的研究。在这篇综述中，我们讨论目前可用于纳米级图案的方法及其优点，以及用于控制纳米级的材料表面化学的技术，而不改变纳米复印件，真正地在纳米级上表征表面化学的可能性。然后，我们讨论目前对细胞如何与纳米级和纳米覆盖物的效果相互作用的细胞与底物之间如何与纳米泡的效果相互作用的知识。此外，细胞底物相互作用是通过蛋白质的存在介导的，所述蛋白质吸附于基材上的生物流体。许多问题仍然存在纳米复印件对蛋白质吸附的影响。我们审查了与这一点相关的论文。随着所有这些参数对细胞反应有影响，重要的是要制定具体研究以指出它们的相对影响，以及对纳米复印术的细胞应答的生物机制。这将是该领域未来研究的基础。组织工程中的一个重要课题是纳米级地形对细菌的影响，因为细胞必须在许多环境中与细菌竞争。鉴于使用地形促进细胞粘合，同时限制细菌粘附，还讨论了该主题的有限目的知识。我们还讨论了纳米级细胞表面相互作用的当前和预期应用。最后，基于先前仍有待解决的问题的问题，我们提出了未来材料科学研究的方向，以帮助阐明纳米复印件对细菌和细胞反应的相对影响，以促进贡献纳米能力的发展。

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