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首页> 外文期刊>Acta crystallographica. Section C, Structural chemistry. >Nobiletin: a citrus flavonoid displaying potent physiological activity
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Nobiletin: a citrus flavonoid displaying potent physiological activity

机译：Nobiletin：柑橘类黄酮显示有效的生理活动

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摘要

Nobiletin [systematic name: 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-4i/-chromen-4-one; C^if^Og] is a flavonoid found in citrus peels, and has been reported to show a wide range of physiological properties, including anti-inflammatory, anticancer and antidementia activities. We have solved the crystal structure of nobiletin, which revealed that the chromene and arene rings of its flavone moiety, as well as the two methoxy groups bound to its arene ring, were coplanar. In contrast, the C atoms of the four methoxy groups bound to the chromene ring are out of the plane, making the molecule conformationally chiral. A comparison of the crystal structures of nobiletin revealed that it could adopt a variety of different conformations through rotation of the covalent bond between the chromene and arene rings, and the orientations of methoxy groups bound to the chromene ring.
机译：Nobiletin [系统名称：2-（3,4-二甲氧基苯基）-5,6,7,8-四甲氧基-4i / -Chromen-4-one; C ^如果^ og]是在柑橘皮中发现的黄酮类化合物，并据报道，展示了各种生理特性，包括抗炎，抗癌和防水活动。 我们已经解决了Nobiletin的晶体结构，揭示了其黄酮部分的铬和芳烃环，以及与其芳环结合的两种甲氧基是共面的。 相反，与铬环结合的四个甲氧基的C原子是从平面中的，使得分子构象性细胞。 Nobiletin晶体结构的比较显示，通过铬烯和芳烃环之间的共价键的旋转，可以采用各种不同的构象，以及与铬环结合的甲氧基的取向。

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