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首页> 外文期刊>Cytokine >Exercise-induced anti-inflammatory effects in overweight/obese women with polycystic ovary syndrome
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Exercise-induced anti-inflammatory effects in overweight/obese women with polycystic ovary syndrome

机译：具有多囊卵巢综合征的超重/肥胖女性的运动诱导的抗炎作用

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Polycystic ovary syndrome (PCOS) is characterized by exacerbated inflammation, which is implicated in cardiometabolic dysfunction. This study aimed to examine the potential effects of acute exercise on inflammatory responses in obese/overweight PCOS women and their controls. Participants underwent a single bout of moderate-intensity aerobic exercise (30 min at similar to 65% of VO2peak). Blood and muscle samples were collected immediately before (PRE) and 60 min after the exercise session. Cytokines (i.e., IL-1 beta, IL-6, IL-4, IL-10, TNF-alpha) were measured both in plasma and in skeletal muscle, and proteins related to inflammatory signaling (IKK alpha/beta and JNK) were assessed in skeletal muscle. At PRE, PCOS showed elevated muscle TNF-alpha (+62%, p = 0.0012) and plasma IL-1 beta (+76%, p = 0.0010) compared to controls. In PCOS, exercise decreased plasma and muscle TNF-alpha (-14%, p = 0.0003 and -46%, p = 0.0003), as well as increased plasma and muscle IL-4 (+147%, p = 0.0018 and +62%, p = 0.0474) and plasma IL-10 (+38%, p = 0.0029). Additionally, IKK alpha/beta and JNK phosphorylation in skeletal muscle, which was higher in PCOS at PRE, was significantly reduced by exercise (-58%, p < 0.0001 and -46%, p < 0.0001, respectively), approaching control levels. Person's correlations between PRE values and delta changes (i.e., exercise effect) showed significant, negative associations for plasma IL-1 beta (r = -0.92, p < 0.0001), TNF-alpha (r = -0.72, p = 0.0100) and IL-6 (r = -0.58, p = 0.05), and muscle INF-alpha (r = -0.95, p < 0.0001), IKK alpha/beta (r = -0.75, p = 0.005), and JNK (r = -0.94, p < 0.0001) in PCOS. In conclusion, exercise can mitigate the inflammatory milieu in women with PCOS. The anti-inflammatory role of exercise could underlie its cardiometabolic protection in PCOS.
机译：多囊卵巢综合征（PCOS）的特征在于加剧炎症，其涉及心细偶差异的功能障碍。本研究旨在研究急性运动对肥胖/超重PCOS女性及其对照中炎症反应的潜在影响。参与者经历了一个中等强度的有氧运动（30分钟的vo2peak的65％）。在运动会后立即收集血液和肌肉样品和60分钟。在血浆和骨骼肌中测量细胞因子（即IL-1β，IL-6，IL-4，IL-10，TNF-α），与炎症信号传导（IKKα/ BETA和JNK相关的蛋白质在骨骼肌中评估。在预先，与对照组相比，PCOS显示出肌肉TNF-α（+ 62％，p = 0.0012）和血浆IL-1β（+ 76％，P = 0.0010）。在PCOS中，运动减少血浆和肌肉TNF-α（-14％，P = 0.0003和-46％，P = 0.0003），以及增加的血浆和肌肉IL-4（+ 147％，P = 0.0018和+62 ％，p = 0.0474）和血浆IL-10（+ 38％，p = 0.0029）。此外，在PROP的PCOS骨骼肌中的IKKα/β和JNK磷酸化在PCOS中较高，通过运动（-58％，P <0.0001和-46％，P <0.0001），接近控制水平。 PER值和DELTA之间的相关性改变（即，运动效果）显示出血浆IL-1β（R = -0.92，P <0.01），TNF-α（R = -0.72，P = 0.0100）和IL-6（r = -0.58，p = 0.05）和肌肉inf-alpha（r = -0.95，p <0.0001），ikk alpha / beta（r = -0.75，p = 0.005）和jnk（r = -0.94，P <0.0001）在PCOS中。总之，锻炼可以减轻PCOS妇女的炎症性环境。锻炼的抗炎作用可能使其在PCOS中的心脏异构保护。

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