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首页> 外文期刊>Cytokine >Genetic variants in IL-33/ST2 pathway with the susceptibility to hepatocellular carcinoma in a Chinese population
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Genetic variants in IL-33/ST2 pathway with the susceptibility to hepatocellular carcinoma in a Chinese population

机译：IL-33 / ST2途径的遗传变异伴中国人群中肝细胞癌的敏感性

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Interleukin (IL)-33/ST2 pathway plays a pivotal role in tumorigenesis through influencing cancer sternness, tumor growth, metastasis, angiogenesis, and accumulation of regulatory T cells in tumor microenvironments. The aim of this study was to investigate the association of IL-33 rs7025417 and ST2 rs3821204 with the risk of hepatocellular carcinoma (HCC). Genotyping of IL-33 rs7025417 and ST2 rs3821204 was carried out using a Taqman assay. IL-33 and ST2 mRNA was examined using real-time PCR and plasma IL-33 and sST2 levels were measured using enzyme-linked immunosorbent assay. The ST2 rs3821204 CC genotype was associated with a significantly increased risk of HCC (CC vs. GG: adjusted OR = 2.29, 95% CI, 1.39-3.78; dominant model: adjusted OR = 1.58, 95% CI, 1.12-2.23; recessive model: adjusted OR = 1.88, 95% CI, 1.21-2.93; C vs. G: adjusted OR = 1.53, 95% CI, 1.20-1.95). Gene-environment interaction analysis showed that the risk effect of rs3821204 CG/CC genotypes was more evident in smokers (adjusted OR = 1.70, 95% CI, 1.13-2.55) and drinkers (adjusted OR = 1.57, 95% CI, 1.04-2.37). The increased risk was also observed in combined analysis. Moreover, HCC patients with ST2 rs3821204 CC genotype had higher levels of mRNA and protein expression (P < 0.05). These findings suggest that ST2 rs3821204 CC genotype may contribute to hepatocarcinogenesis by enhancing ST2 production at the transcriptional and translational level.
机译：白细胞介素（IL）-33 / ST2途径通过影响癌症沉默，肿瘤生长，转移，血管生成和肿瘤微环境中调节性T细胞的积累在肿瘤发生中起着枢轴作用。本研究的目的是研究IL-33 RS7025417和ST2 RS3821204与肝细胞癌（HCC）的风险的关联。使用Taqman测定进行IL-33 RS7025417和ST2 RS3821204的基因分型。使用实时PCR检测IL-33和ST2 mRNA，使用酶联免疫吸附测定测量血浆IL-33和SST2水平。 ST2 RS3821204 CC基因型与HCC的显着增加有关（CC与GG：调整后的或= 2.29,95％CI，1.39-3.78;主导模型：调整或= 1.58,95％CI，1.12-2.23;隐性型号：调整或= 1.88,95％CI，1.21-2.93; C与G：调整或= 1.53,95％CI，1.20-1.95）。基因环境相互作用分析表明，吸烟者（调整或= 1.70,95％CI，1.13-2.55）和饮酒者（调整或= 1.57，95％CI，1.04-2.37）更明显的风险效应更明显）。在组合分析中也观察到风险增加。此外，HCC患者ST2 RS3821204 CC基因型具有较高水平的mRNA和蛋白质表达（P <0.05）。这些发现表明，ST2 RS3821204 CC基因型可通过增强转录和平移水平的增强ST2产生来促进肝癌发生。

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