IL-17 family: Cytokines, receptors and signaling

GuC.; WuL.; LiX.

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IL-17 family: Cytokines, receptors and signaling

机译：IL-17家族：细胞因子，受体和信号

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The interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in host defense against microbial organisms and in the development of inflammatory diseases. Although IL-17A is the signature cytokine produced by T helper 17 (Th17) cells, IL-17A and other IL-17 family cytokines have multiple sources ranging from immune cells to non-immune cells. The IL-17 family signals via their correspondent receptors and activates downstream pathways that include NFκB, MAPKs and C/EBPs to induce the expression of anti-microbial peptides, cytokines and chemokines. The proximal adaptor Act1 is a common mediator during the signaling of all IL-17 cytokines so far and is thus involved in IL-17 mediated host defense and IL-17-driven autoimmune conditions. This review will give an overview and recent updates on the IL-17 family, the activation and regulation of IL-17 signaling as well as diseases associated with this cytokine family.

机译：白细胞介素17（IL-17）家族是由IL-17A-F组成的细胞因子的子集在宿主对微生物生物和炎症性疾病的发展中起着至关重要的作用。虽然IL-17A是由T辅助17（TH17）细胞产生的特征细胞因子，但IL-17A和其他IL-17家族细胞因子具有从免疫细胞到非免疫细胞的多个源。 IL-17系列信号通过它们的对应受体发出并激活包括NFκB，MAPK和C / EBP的下游途径，以诱导抗微生物肽，细胞因子和趋化因子的表达。近端适配器ACT1是迄今为止所有IL-17细胞因子的信号传导过程中的常用介体，因此涉及IL-17介导的宿主防御和IL-17驱动的自身免疫条件。本综述将概述IL-17系列的概述和最新更新，IL-17信号传导的激活和调节以及与该细胞因子家族相关的疾病。

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《Cytokine》 |2013年第2期|共9页
作者
GuC.; WuL.; LiX.;
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作者单位

Department of Immunology Lerner Research Institute Cleveland Clinic Foundation OH United States;

Department of Immunology Lerner Research Institute Cleveland Clinic Foundation OH United States;

Department of Immunology Lerner Research Institute Cleveland Clinic Foundation OH United States;

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原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
Act1; IL-17R; Interleukin 17; Signaling transduction;

机译：ACT1;IL-17R;白细胞介素17;信号转导;

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专利

1. IL-17 family: Cytokines, receptors and signaling [J] . GuC., WuL., LiX. Cytokine . 2013,第2期

机译：IL-17家族：细胞因子，受体和信号
2. Inflammatory Cytokines IL-32 and IL-17 Have Common Signaling Intermediates despite Differential Dependence on TNF-Receptor 1 [J] . Emily Turner-Brannen, Ka-Yee Grace Choi, Ryan Arsenault, The journal of immunology . 2011,第12期

机译：尽管对TNF-受体1的依赖性不同，但炎性细胞因子IL-32和IL-17具有常见的信号传导中间物。
3. Inflammatory cytokines IL-32 and IL-17 have common signaling intermediates despite differential dependence on TNF-receptor 1. [J] . Turner Brannen E, Choi KY, Arsenault R, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2011,第12期

机译：尽管对TNF受体1的依赖性不同，但炎性细胞因子IL-32和IL-17具有常见的信号传导中间体。
4. The interleukin-1 family cytokines and receptors in autoimmune and autoinflammatory diseases [C] . Lucchesi D., Anzilotti C., Del Corso I., European Congress of Immunology . 2009

机译：自身免疫和自身炎症疾病中白细胞介素-1家族细胞因子和受体
5. Suppressor of cytokine signaling-2 (SOCS2) and epidermal growth factor (EGF) modulate insulin-like growth factor-I receptor (IGF-IR) signaling in intestinal cancer. [D] . Newton, Victoria A. 2010

机译：细胞因子信号传导抑制因子2（SOCS2）和表皮生长因子（EGF）的抑制因子调节肠癌中胰岛素样生长因子-I受体（IGF-IR）的信号传导。
6. IL-17 family: cytokines receptors and signaling [O] . Chunfang Gu, Ling Wu, Xiaoxia Li -1

机译：IL-17家族：细胞因子受体和信号传导
7. IL-17 family: Cytokines, receptors and signaling [O] . Chunfang Gu, Ling Wu, Xiaoxia Li 2013

机译：IL-17家族：细胞因子，受体和信号

IL-17 family: Cytokines, receptors and signaling

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