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Serum biomarker analysis in patients with premature ovarian insufficiency

机译：患有过早卵巢功能不全的患者的血清生物标志物分析

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摘要

Premature ovarian insufficiency (POI) is a primary ovarian defect characterized by premature depletion of ovarian follicles before 40 years of age. The disorder has been attributed to various causes, but the study of altered proteins in serum levels as the cause is rare. Additionally, identifying novel biomarkers can contribute to more accurate diagnosis or prognosis of POI. In the present study, a solid-phase antibody array simultaneously detecting multiple proteins was used to analyze POI serum with menopausal and healthy fertile subjects as control groups. As a result, compared to the menopause and healthy fertile groups, eleven proteins, including Neurturin, Frizzled-5, Serpin Dl, MMP-7, ICAM-3, IL-17F, IFN-gamma R1, IL-29, IL-17R, IL-17C and Soggy-1, were uniquely down-regulated, and Afamin was particularly up-regulated in POI serum. More importantly, all of these factors were firstly found to be associated with POI in this study, suggesting that these proteins may participate in the pathogenesis of POI and may be novel serum biomarkers for POI.
机译：过早的卵巢不足（POI）是一种主要卵巢缺陷，其特征在于40岁之前的卵巢卵泡过早耗尽。这种疾病已归因于各种原因，但随着原因的血清水平改变的蛋白质的研究是罕见的。此外，鉴定新型生物标志物可以有助于更准确的POI诊断或预后。在本研究中，使用同时检测多种蛋白质的固相抗体阵列分析具有更年期和健康肥沃受试者的POI血清作为对照组。结果，与更年期和健康的肥沃群体相比，11个蛋白质，包括神经蛋白，Frizzled-5，Serpin D1，MMP-7，ICAM-3，IL-17F，IFN-Gamma R1，IL-29，IL-17R ，IL-17C和Soggy-1是独特的下调，AFAMIN在POI血清中特别上调。更重要的是，首先发现所有这些因素都与本研究中的POI有关，表明这些蛋白质可以参与POI的发病机制，并且可以是POI的新型血清生物标志物。

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  • 来源
    《Cytokine》 |2020年第2020期|共7页
  • 作者

    Liu Jian; Huang Xunchun; Cao Xiaojing; Feng Xuan; Wang Xiaoyun;

  • 作者单位

    Guangzhou Univ Chinese Med Affiliated Hosp 2 Dept Gynecol 111 Dade Rd Guangzhou 510000;

    Guangzhou Univ Chinese Med Affiliated Hosp 2 Dept Gynecol 111 Dade Rd Guangzhou 510000;

    Guangzhou Univ Chinese Med Affiliated Hosp 2 Dept Gynecol 111 Dade Rd Guangzhou 510000;

    Guangzhou Univ Chinese Med Affiliated Hosp 2 Dept Gynecol 111 Dade Rd Guangzhou 510000;

    Guangzhou Univ Chinese Med Affiliated Hosp 2 Dept Gynecol 111 Dade Rd Guangzhou 510000;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    Premature ovarian insufficiency; Menopause; Biomarker; Antibody array;

    机译：过早卵巢功能不全;更年期;生物标志物;抗体阵列;

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