Predictive value of low interleukin-33 in critically ill patients

Krychtiuk Konstantin A.; Stojkovic Stefan; Lenz Max; Brekalo Mira; Huber Kurt; Wojta Johann; Heinz Gottfried; Demyanets Svitlana; Speidl Walter S.

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Predictive value of low interleukin-33 in critically ill patients

机译：低白细胞介素-33在批判性患者中的预测值

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Patients admitted to a medical intensive care unit (ICU) are characterized by an activated immune system and exhibit a high mortality rate irrespective of the underlying cause of admission. Interleukin (IL)-33 has been shown to be protective in experimental sepsis models and it has been demonstrated that circulating levels of its "decoy" receptor soluble ST2 (sST2) are associated with outcome in critically ill patients. The aim of the present study was to investigate whether circulating IL-33 is associated with 30-day mortality in patients admitted to a medical ICU. In this prospective, observational study, both IL-33 and sST2 levels were assessed in 223 consecutive patients at ICU admission using specific enzyme-linked immunosorbent assays (ELISAs). During the 30-day follow-up, 58 patients (26%) died. Circulating IL-33 was detectable in 166 patients and in 57 patients, serum IL-33 was below the detection limit. Both detectable IL-33 and sST2 below the median were strong predictors of survival in critically ill patients independent of acute physiology and chronic health evaluation II (APACHE II) score. IL-33 and sST2 predicted risk independent from each other. Patients with both, non-detectable levels of IL-33 and sST2 levels above the median, showed a dramatically increased mortality risk (HR 6.9 95% CI 3.0-16.2; p 0.001). Low levels of IL-33 and increased levels of sST2 predict mortality risk in critically ill patients independent from each other and APACHE II score. Both together showed additive predictive value suggesting a pathogenic role of the IL-33/ST2 system in critically ill patients.

机译：患有医疗重症监护病房（ICU）的患者的特征在于激活的免疫系统，而且与入学潜在原因无关表现出高死亡率。白细胞介素（IL）-33已被证明在实验性脓毒症模型中是保护性的，并且已经证明其“诱饵”受体可溶性ST2（SST2）的循环水平与重症患者的结果相关。本研究的目的是研究循环IL-33是否与入院医疗ICU的患者的30天死亡率有关。在这种前瞻性的，观察性研究中，使用特定酶联免疫吸附测定（ELISAS）在ICU入院的223名患者中评估IL-33和SST2水平。在30天的随访期间，58名患者（26％）死亡。在166名患者和57名患者中可检测到循环IL-33，血清IL-33低于检测限。低于中位数的可检测的IL-33和SST2都是危重病患者的生存患者的强预测因子，与急性生理学和慢性健康评估II（Apache II）得分。 IL-33和SST2预测风险独立于彼此。患有IL-33和中值的IL-33和SST2水平的患者，表现出显着增加的死亡率风险（HR 6.9 95％CI 3.0-16.2; P <0.001）。低水平的IL-33和SST2水平增加预测患有彼此独立的患者和Apache II得分的危重病人的死亡率风险。两者都表现出添加剂预测值，表明IL-33 / ST2系统在批判性患者中的病原作用。

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《Cytokine》 |2018年第2018期|共5页
作者
Krychtiuk Konstantin A.; Stojkovic Stefan; Lenz Max; Brekalo Mira; Huber Kurt; Wojta Johann; Heinz Gottfried; Demyanets Svitlana; Speidl Walter S.;
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作者单位

Med Univ Vienna Div Cardiol Dept Internal Med 2 Waehringer Guertel 18-20 A-1090 Vienna Austria;

Med Univ Vienna Div Cardiol Dept Internal Med 2 Waehringer Guertel 18-20 A-1090 Vienna Austria;

Med Univ Vienna Div Cardiol Dept Internal Med 2 Waehringer Guertel 18-20 A-1090 Vienna Austria;

Med Univ Vienna Div Cardiol Dept Internal Med 2 Waehringer Guertel 18-20 A-1090 Vienna Austria;

Ludwig Boltzmann Cluster Cardiovasc Res Waehringer Guertel 18-20 A-1090 Vienna Austria;

Med Univ Vienna Div Cardiol Dept Internal Med 2 Waehringer Guertel 18-20 A-1090 Vienna Austria;

Med Univ Vienna Div Cardiol Dept Internal Med 2 Waehringer Guertel 18-20 A-1090 Vienna Austria;

Med Univ Vienna Dept Lab Med Waehringer Guertel 18-20 A-1090 Vienna Austria;

Med Univ Vienna Div Cardiol Dept Internal Med 2 Waehringer Guertel 18-20 A-1090 Vienna Austria;

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正文语种 eng
中图分类细胞生物学;
关键词
Interleukin-33; Soluble ST2; SIRS; Critical care; 30-day mortality;

机译：白细胞介素-33;可溶性ST2;SIRS;关键护理;30天死亡率;

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机译：低白细胞介素-33在批判性患者中的预测值
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Predictive value of low interleukin-33 in critically ill patients

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