Lack of chemokine (C-C motif) ligand 3 leads to decreased survival and reduced immune response after bacterial meningitis

Aust Vanessa; Kress Eugenia; Abraham Stephanie; Schroeder Nicole; Kipp Markus; Stope Matthias B.; Pufe Thomas; Tauber Simone C.; Brandenburg Lars-Ove

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Lack of chemokine (C-C motif) ligand 3 leads to decreased survival and reduced immune response after bacterial meningitis

机译：缺乏趋化因子（C-C图谱）配体3导致细菌性脑膜炎后的存活率降低和减少免疫应答

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Pneumococcal meningitis, caused by Streptococcus pneumoniae, is the most common type of bacterial meningitis. The clinical management of this disease has been challenged by the emergence of multidrug-resistant Streptococcus pneumoniae, requiring the urgent development of new therapeutic alternatives. Over the course of bacterial meningitis, pathogen invasion is accompanied by a massive recruitment of peripheral immune cells, especially neutrophil granulocytes, which are recruited under the coordination of several cytokines and chemokines. Here, we used chemokine (C-C motif) ligand 3 (Ccl3)-deficient mice to investigate the functional role of CCL3 in a mouse model of pneumococcal meningitis.

机译：肺炎球菌脑膜炎，由链球菌引起的，是最常见的细菌性脑膜炎类型。这种疾病的临床管理受到多药中肺炎链球菌的出现挑战，需要紧急开发新的治疗方法。在细菌性脑膜炎的过程中，病原体侵袭伴随着大量募集外周免疫细胞，特别是中性粒细胞粒细胞，这些细胞粒细胞在几种细胞因子和趋化因子的协调下招募。在这里，我们使用趋化因子（C-C硅酰基）配体3（CCL3） - 缩义小鼠来研究CCL3在肺炎球菌脑膜炎小鼠模型中的功能作用。

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来源
《Cytokine》 |2018年第2018期|共9页
作者
Aust Vanessa; Kress Eugenia; Abraham Stephanie; Schroeder Nicole; Kipp Markus; Stope Matthias B.; Pufe Thomas; Tauber Simone C.; Brandenburg Lars-Ove;
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作者单位

Rhein Westfal TH Aachen Dept Anat &

Cell Biol Wendlingweg 2 D-52074 Aachen Germany;

Rhein Westfal TH Aachen Dept Anat &

Cell Biol Wendlingweg 2 D-52074 Aachen Germany;

Rhein Westfal TH Aachen Dept Anat &

Cell Biol Wendlingweg 2 D-52074 Aachen Germany;

Rhein Westfal TH Aachen Dept Anat &

Cell Biol Wendlingweg 2 D-52074 Aachen Germany;

Ludwig Maximilians Univ Munchen Dept Anat 2 Munich Germany;

Univ Med Greifswald Dept Urol Greifswald Germany;

Rhein Westfal TH Aachen Dept Anat &

Cell Biol Wendlingweg 2 D-52074 Aachen Germany;

RWTH Univ Hosp Aachen Dept Neurol Aachen Germany;

Rhein Westfal TH Aachen Dept Anat &

Cell Biol Wendlingweg 2 D-52074 Aachen Germany;

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原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
Bacterial meningitis; Chemokine; CCL3; MIP-1-alpha; Glial cell; Innate immunity; Streptococcus pneumoniae;

机译：细菌脑膜炎;趋化因子;CCL3;MIP-1-α;胶质细胞;先天免疫;链球菌肺炎;

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1. Lack of chemokine (C-C motif) ligand 3 leads to decreased survival and reduced immune response after bacterial meningitis [J] . Aust Vanessa, Kress Eugenia, Abraham Stephanie, Cytokine . 2018,第期

机译：缺乏趋化因子（C-C图谱）配体3导致细菌性脑膜炎后的存活率降低和减少免疫应答
2. Absence of C-C motif chemokine ligand 5 in mice leads to decreased local macrophage recruitment and behavioral hypersensitivity in a murine neuropathic pain model [J] . LiouJ.-T., YuanH.-B., MaoC.-C., Pain. . 2012,第6期

机译：在小鼠中缺乏C-C基序趋化因子配体5导致鼠神经性疼痛模型中局部巨噬细胞募集减少和行为超敏反应
3. Chemokine (C-C motif) ligand 2 and chemokine (C-C motif) ligand 7 in angle-closure glaucoma [J] . Gao Xinbo, Huang Wenbin, Zhang Xiulan, Acta ophthalmologica . 2016,第3期

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4. DOES A TH17 SKEWED IMMUNE RESPONSE IN STEROID-RESPONSIVE MENINGITIS-ARTERITIS EXIST? [C] . Andrea Tipold, Jessica Freundt-Revilla Conference of the American^College^of^Veterinary^Internal^Medicine . 2016

机译：存在类固醇敏感性脑膜炎的TH17偏见的免疫应答吗？
5. Treatment of Staphylococcus aureus Infection by Hematopoietic Stem and Progenitor Cells and the Role of Chemokine C-C Motif Receptor 6 in Wound Healing [D] . Anderson, Leif Stefan. 2019

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Lack of chemokine (C-C motif) ligand 3 leads to decreased survival and reduced immune response after bacterial meningitis

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