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首页> 外文期刊>Cytokine >Extensive serum biomarker analysis in patients with non-small-cell lung carcinoma
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Extensive serum biomarker analysis in patients with non-small-cell lung carcinoma

机译：非小细胞肺癌患者的广泛血清生物标志物分析

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摘要

Lung cancer is a common malignant disease, nearly 2.09 million new patients occurred last year. Approximately 85% of the patients are classified as non-small-cell lung cancer (NSCLC). It is therefore important to identify new diagnostic and prognostic biomarkers for the early detection of this disease. The presented study identifies biomarkers in the serum of NSCLC patients. The expression of 274 cytokines was measured by a novel antibody array methodology and ELISA was applied to validate the array results. The levels of MIP-1 alpha, IL-8, MIP-1 beta, Resistin, GDF-15, HGF, CA125, FLRG, VCAM-1, DKK-3, sTNF-R1, CTACK, Acrp30, CXCL-16 and LYVE-1 were significantly higher in serum from NSCLC patients, while the level of TIMP-2 and IGFBP-6 were lower. More importantly, the validation supported the result of the antibody array. The result of the antibody array indicates that these cytokines might be novel auxiliary biomarkers in the diagnosis and prognosis of NSCLC.
机译：肺癌是一种常见的恶性疾病，去年近290万名患者发生。 大约85％的患者被归类为非小细胞肺癌（NSCLC）。 因此，重要的是识别新的诊断和预后生物标志物，用于早期发现这种疾病。 本研究识别NSCLC患者血清中的生物标志物。 通过新型抗体阵列方法测量274个细胞因子的表达，并施加ELISA以验证阵列结果。 MIP-1α，IL-8，MIP-1β，抵抗汀，GDF-15，HGF，CA125，FLRG，VCAM-1，DKK-3，STNF-R1，CTACK，ACRP30，CXCL-16和LYVE 来自NSCLC患者的血清中血清显着高，而TIMP-2和IGFBP-6水平较低。 更重要的是，验证支持抗体阵列的结果。 抗体阵列的结果表明，这些细胞因子可能是NSCLC诊断和预后的新型辅助生物标志物。

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  • 来源
    《Cytokine》 |2020年第2020期|共9页
  • 作者

    Cai Donghao; Xu Ying; Ding Rui; Qiu Kaifeng; Zhang Ruihua; Wang Han; Huang Lisi; Xie Xiaoying; Yan Haiyan; Deng Yawen; Lin Xianghua; Shao Jing; Luo Xiaohong; Duan Chaohui;

  • 作者单位

    Sun Yat Sen Univ Sun Yat Sen Mem Hosp Lab Clin Guangzhou 510120 Peoples R China;

    Sun Yat Sen Univ Sun Yat Sen Mem Hosp Lab Clin Guangzhou 510120 Peoples R China;

    Sun Yat Sen Univ Sun Yat Sen Mem Hosp Lab Clin Guangzhou 510120 Peoples R China;

    Sun Yat Sen Univ Sun Yat Sen Mem Hosp Guangdong Prov Key Lab Malignant Tumor Epigenet &

    Sun Yat Sen Univ Sun Yat Sen Mem Hosp Lab Clin Guangzhou 510120 Peoples R China;

    Sun Yat Sen Univ Sun Yat Sen Mem Hosp Lab Clin Guangzhou 510120 Peoples R China;

    Sun Yat Sen Univ Sun Yat Sen Mem Hosp Lab Clin Guangzhou 510120 Peoples R China;

    Sun Yat Sen Univ Sun Yat Sen Mem Hosp Lab Clin Guangzhou 510120 Peoples R China;

    Sun Yat Sen Univ Sun Yat Sen Mem Hosp Lab Clin Guangzhou 510120 Peoples R China;

    Sun Yat Sen Univ Sun Yat Sen Mem Hosp Lab Clin Guangzhou 510120 Peoples R China;

    Sun Yat Sen Univ Sun Yat Sen Mem Hosp Lab Clin Guangzhou 510120 Peoples R China;

    Sun Yat Sen Univ Sun Yat Sen Mem Hosp Guangdong Prov Key Lab Malignant Tumor Epigenet &

    Sun Yat Sen Univ Sun Yat Sen Mem Hosp Lab Clin Guangzhou 510120 Peoples R China;

    Sun Yat Sen Univ Sun Yat Sen Mem Hosp Lab Clin Guangzhou 510120 Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    Non-small-cell lung cancer; Serum biomarker; Antibody array;

    机译：非小细胞肺癌;血清生物标志物;抗体阵列;

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