Immune cell infiltration in head and neck squamous cell carcinoma and patient outcome: a retrospective study

Schneider Karolin; Marbaix Etienne; Bouzin Caroline; Hamoir Marc; Mahy Pierre; Bol Vanesa; Gregoire Vincent

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Immune cell infiltration in head and neck squamous cell carcinoma and patient outcome: a retrospective study

机译：头部和颈部鳞状细胞癌和患者结果中的免疫细胞浸润：回顾性研究

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Background: Human papillomavirus (HPV) prevalence in oropharynx squamous cell carcinoma (OPSCC) is on the rise. HPV-linked OPSCCs represent a distinct clinical entity with a better treatment response and patient survival compared to tumors not linked to HPV. An emerging role in treatment response has been attributed to immune cell infiltration in human tumors. In this study, we investigated immune cell infiltration in human SCC of the head and neck region and its relation to overall survival after treatment with surgery (with or without radiotherapy) or concomitant chemo (or cetuximab)-radiotherapy.

机译：背景：人乳头瘤病毒（HPV）患有oropharynx鳞状细胞癌（OPSCC）的普遍存在。 HPV-LINKED OPSCC与未与HPV相关联的肿瘤相比，具有更好的治疗响应和患者存活的不同临床实体。治疗反应中的新兴作用归因于人类肿瘤的免疫细胞浸润。在这项研究中，我们研究了头部和颈部地区的人SCC中的免疫细胞浸润，并在用手术治疗后与整体存活的关系（有或没有放射疗法）或伴随的化疗（或Cetuximab）-RadiOurapy。

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来源
《Acta oncologica.》 |2018年第9期|共8页
作者
Schneider Karolin; Marbaix Etienne; Bouzin Caroline; Hamoir Marc; Mahy Pierre; Bol Vanesa; Gregoire Vincent;
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作者单位

Catholic Univ Louvain Ctr Mol Imaging Radiotherapy &

Oncol MIRO Inst Expt &

Clin Res IREC;

St Luc Univ Hosp Dept Pathol Brussels Belgium;

Catholic Univ Louvain Inst Expt &

Clin Res IREC IREC Imaging Platform Brussels Belgium;

St Luc Univ Hosp King Albert II Canc Inst Dept Otorhinolaryngol &

Head &

Neck Surg Brussels;

St Luc Univ Hosp King Albert II Canc Inst Dept Stomatol &

Maxillofacial Surg Brussels Belgium;

Catholic Univ Louvain Ctr Mol Imaging Radiotherapy &

Oncol MIRO Inst Expt &

Clin Res IREC;

Catholic Univ Louvain Ctr Mol Imaging Radiotherapy &

Oncol MIRO Inst Expt &

Clin Res IREC;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
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1. Immune cell infiltration in head and neck squamous cell carcinoma and patient outcome: a retrospective study [J] . Schneider Karolin, Marbaix Etienne, Bouzin Caroline, Acta oncologica. . 2018,第9期

机译：头部和颈部鳞状细胞癌和患者结果中的免疫细胞浸润：回顾性研究
2. pN status predicts outcomes in surgically treated pT1-pT2 patients of various disease stages with squamous cell carcinoma of the head and neck: a 17-year retrospective single center cohort study [J] . Qian Xu, Sinikovic Branko, Schreiber Frank, European archives of oto-rhino-laryngology: Official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) . 2018,第11期

机译：PN状态预测手术治疗的PT1-PT2患者的结果与头部和颈部的鳞状细胞癌：17年的回顾单中心队列研究
3. Heat shock protein 70 and tumor‐infiltrating NK cells as prognostic indicators for patients with squamous cell carcinoma of the head and neck after radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Radiation Oncology Group (DKTK‐ROG) [J] . Stangl Stefan, Tontcheva Nikoletta, Sievert Wolfgang, International Journal of Cancer =: Journal International du Cancer . 2018,第9期

机译：热休克蛋白70和肿瘤浸润的NK细胞作为预后鳞状细胞癌患者的预后指标：放射性化学治疗后的头部和颈部：德国癌症联盟肿瘤肿瘤学群的多期回顾性研究（DKTK-ROG）
4. Up-Regulation of Enhancer of Zeste Homolog 2 Is Associated Positively With Cyclin Dl Overexpression and Poor Clinical Outcome in Head and Neck Squamous Cell Carcinoma [C] . Wei Cao, Zhien Feng, Zhibin Cui, Academic Committee conference of Shanghai key lab of stomatology . 2011

机译：Zeste同源2的增强子的上调与Cyclin Dl过度表达和头颈部鳞状细胞癌的不良临床结果呈正相关。
5. The prognostic potential of the epidermal growth factor receptor and nuclear factor kappa B pathways and associated therapeutic strategies in patients with squamous cell carcinoma of the head and neck. [D] . Wirth, Pamela Susan. 2010

机译：表皮生长因子受体和核因子κB通路对头颈部鳞状细胞癌患者的预后潜力及相关治疗策略。
6. Effect of CXCR5-Positive Cell Infiltration on the Immune Contexture and Patient Prognosis in Head and Neck Squamous Cell Carcinoma [O] . Jun Chen, Xiangchao Meng, Qinyi Zhou, 2020

机译：CXCR5阳性细胞浸润对头部鳞状细胞癌免疫构建和患者预后的影响
7. Real-World, Long-Term Outcomes of Nivolumab Therapy for Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck and Impact of the Magnitude of Best Overall Response: A Retrospective Multicenter Study of 88 Patients [O] . Takashi Matsuki, Isaku Okamoto, Chihiro Fushimi, 2020

机译：现实世界，幼肠病治疗的长期结果，用于颈部复发或转移性鳞状细胞癌，以及最佳整体反应的影响：88例患者的回顾性多中心研究

Immune cell infiltration in head and neck squamous cell carcinoma and patient outcome: a retrospective study

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