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首页> 外文期刊>Cytoskeleton >APC2 associates with the actin cortex through a multipart mechanism to regulate cortical actin organization and dynamics in the Drosophila ovary
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APC2 associates with the actin cortex through a multipart mechanism to regulate cortical actin organization and dynamics in the Drosophila ovary

机译：APC2通过多部分机制与肌动蛋白皮质相关联，以调节果蝇卵巢中的皮质肌动蛋白组织和动态

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Abstract The actin cortex that lines the plasma membrane of most eukaryotic cells resists external mechanical forces and plays critical roles in a variety of cellular processes including morphogenesis, cytokinesis, and cell migration. Despite its ubiquity and significance, we understand relatively little about the composition, dynamics, and structure of the actin cortex. Adenomatous polyposis coli (APC) proteins regulate the actin and microtubule cytoskeletons through a variety of mechanisms, and in some contexts, APC proteins are cortically enriched. Here we show that APC2 regulates cortical actin dynamics in the follicular epithelium and the nurse cells of the Drosophila ovary and in addition affects the distribution of cortical actin at the apical side of the follicular epithelium. To understand how APC2 influences these properties of the actin cortex, we investigated the mechanisms controlling the cortical localization of APC2 in S2 cultured cells. We previously showed that the N‐terminal half of APC2 containing the Armadillo repeats and the C‐terminal 30 amino acids (C30) are together necessary and sufficient for APC2's cortical localization. Our work presented here supports a model that cortical localization of APC2 is governed in part by self‐association through the N‐terminal APC Self‐Association Domain (ASAD) and a highly conserved coiled‐coil within the C30 domain.
机译：摘要大多数真核细胞的血浆膜的肌动蛋白皮质抵抗外部机械力，并在各种细胞过程中起重要作用，包括形态发生，细胞因子和细胞迁移。尽管有难以致力于和意义，但我们对肌动蛋白皮质的组成，动力学和结构相对较少地了解。腺瘤性息肉蛋白Coli（APC）蛋白通过各种机制调节肌动蛋白和微管骨骼细胞骨架，并且在某些情况下，APC蛋白质是半导体富集的。在这里，我们表明APC2调节卵泡上皮中的皮质肌动蛋白动态，果蝇卵巢的护士细胞和另外影响皮质肌动蛋白在滤色上皮的顶端侧的分布。要了解APC2如何影响肌动蛋白皮质的这些性质，我们研究了控制S2培养细胞中APC2的皮质定位的机制。我们以前表明，含有Armadillo重复和C末端30氨基酸（C30）的APC2的N-末端半部是必需的，并且足以用于APC2的皮质定位。我们在此提供的工作支持APC2的皮质定位的模型部分通过N终端APC自交联域（ASAD）和高度保守的卷线圈在C30域内的高度保守的卷线圈来管理。

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