Crystal and molecular structure and stability of isoniazid cocrystals with selected carboxylic acids

Sarcevica I.; Orola L.; Veidis M.V.; Podjava A.; Belyakov S.

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Crystal and molecular structure and stability of isoniazid cocrystals with selected carboxylic acids

机译：具有选定羧酸的异烟肼共晶体的晶体，分子结构和稳定性

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Reaction of isoniazid with benzoic acid, sebacic acid, suberic acid, and cinnamic acid results in formation of cocrystals. Two polymorphs of isoniazid-suberic acid and two polymorphs of isoniazid-cinnamic acid cocrystals were isolated. Crystal structure analysis shows the presence of a pyridine-carboxylic acid synthon in the studied cocrystals. The hydrazide group of isoniazid participates in N-H···O and N-H···N hydrogen bond formation, producing different supramolecular synthons. The stability study of isoniazid cocrystals has been performed over a 22 week period. A comparison of melting points of isoniazid-dicarboxylic acid 2:1 cocrystals shows the decrease of melting point with an increasing length of the acid. Solubility of isoniazid-carboxylic acid cocrystals tends to increase with increasing solubility of the acid.

机译：异烟肼与苯甲酸，癸二酸，辛二酸和肉桂酸的反应导致形成共晶体。分离了异烟肼-异丁二酸的两个多晶型物和异烟肼-肉桂酸共结晶的两个多晶型物。晶体结构分析表明，在所研究的共晶体中存在吡啶-羧酸合成子。异烟肼的酰肼基团参与N-H··O和N-H···N氢键的形成，产生不同的超分子合成子。异烟肼共晶体的稳定性研究已经进行了22周。异烟肼-二羧酸2：1共晶体的熔点比较表明，随着酸长度的增加，熔点降低。异烟肼-羧酸共晶体的溶解度趋于随酸的溶解度增加而增加。

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《Crystal growth & design》 |2013年第3期|共9页
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Sarcevica I.; Orola L.; Veidis M.V.; Podjava A.; Belyakov S.;
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1. Crystal and molecular structure and stability of isoniazid cocrystals with selected carboxylic acids [J] . Sarcevica I., Orola L., Veidis M.V., Crystal growth & design . 2013,第3期

机译：具有选定羧酸的异烟肼共晶体的晶体，分子结构和稳定性
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机译：羧酸分子共晶体.25。尿素在用羧酸进行结构制造以及六种与芳香族酸加成反应的晶体结构中的用途
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机译：利用298 K X射线和15 K中子衍射分析4-氨基苯甲酸和3,5-二硝基苯甲酸共晶中的羧酸和胺 - 硝基氢键几何结构

Crystal and molecular structure and stability of isoniazid cocrystals with selected carboxylic acids

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