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首页> 外文期刊>Acta gastro-enterologica Belgica >Patients with primary localized high-grade sarcomas of the digestive tract excluding GIST : a retrospective study from the French sarcoma group
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Patients with primary localized high-grade sarcomas of the digestive tract excluding GIST : a retrospective study from the French sarcoma group

机译：患有初级局部高档肉瘤的消化道，不包括GIST：法国肉瘤集团的回顾性研究

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Introduction : The natural history of localized high-grade sarcomas of the digestive tract (SDT) excluding GIST has been rarely considered owing to their low incidence and heterogeneity. We describe the histoclinical characteristics of SDT and correlate them with patients’ outcomes. Methods : We retrospectively collected medical files from a European database covering connective tissue tumors listed in Europe for about twenty years. Only untreated localized primary high-grade SDT were included. A central histological review was performed for each case. Patients’ characteristics were compared and correlated with clinical outcomes. Results: A total of 45 patients were identified. Leiomyosarcomas (LMS) and undifferentiated sarcomas (UDS) were predominant, the former having better overall survival (OS) and progression-free survival (PFS) while the latter having a worse outcome than the other histological types. Complete remission was obtained in 34 patients (75%) and was associated with male sex, age over 40 years and monofocal tumor. Complete surgery and LMS histology were associated with a better prognosis without any significant difference in baseline characteristics or in treatment modalities. Conclusion : Complete surgery and histological type seem to be prognostic indicators of SDT. These results suggest the importance of treating these patients in a reference center. (Acta gastroenterol.
机译：简介：由于其发病率和异质性低，所以不包括GIST的局部高级肉瘤的自然历史已经很少考虑。我们描述了SDT的组织胶质特征，并与患者的结果相关联。方法：我们回顾性地从欧洲数据库中收集医疗文件，涵盖欧洲的结缔组织肿瘤约20年。仅包括未经处理的局部主要高级SDT。对每种情况进行了中枢组织学审查。患者的特征进行了比较和与临床结果相关。结果：共鉴定了45名患者。 Leiomyosarcomas（LMS）和未分化的肉瘤（UDS）是主要的，前者具有更好的整体存活（OS）和无进展的存活（PFS），而后者具有比其他组织学类型更差的结果。在34名患者中获得完全缓解（75％），与男性性交有关，年龄超过40岁，单焦肿瘤。完整的手术和LMS组织学与更好的预后相关，没有基线特征或治疗方式的任何显着差异。结论：完全手术和组织学类型似乎是SDT的预后指标。这些结果表明在参考中心治疗这些患者的重要性。 （Acta胃肠醇。

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