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A unique case of upper GI bleed

机译:一个独特的上gi出血

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A 57 year-old male chronic alcohol abuse with sarcoidosis on chronic prednisone was admitted with hematemesis. An urgent esopahgogastroduodenoscopy (EGD) showed old blood clots without any evidence of active bleeding. Repeat EGD after 72 hrs revealed a large well demarcated ulcer with raised and hyperemic edges involving the fundus and lesser curvature (Fig. A & B). The base of the ulcer was very friable and covered with necrotic slough. What is the etiology? Biopsies taken from the edge of the ulcer showed numerous variably sized, 90° angulated fungal hyphae favoring mucormycosis with evidence of capillary invasion (Fig. C). The patient was not deemed a surgical candidate for gastrectomy due to disseminated mucormycosis involving the urinary bladder. The patient was started on intravenous therapy and bladder irrigation using Amphotericin B. The patient was discharged home on Isavuconazonium for total of 6 months.
机译:血液化患有57岁的男性慢性酒精滥用慢性泼尼松的慢性泼尼松。 紧急esopahgogastroduodenoscoce(EGD)显示旧血栓,没有任何有效出血的证据。 72小时后重复EGD,揭示了涉及眼底和较小曲率的凸起和血液边缘的大井划分性溃疡(图。a&b)。 溃疡的碱是非常易碎的,并用坏死的泥沼覆盖。 什么是病因? 从溃疡的边缘取出的活组织检查显示了许多可变大小的90°角落的真菌菌丝,含有毛细管侵袭的证据(图C)。 由于涉及膀胱的缺陷粘糊蛋白,患者未被视为胃切除术的外科候选者。 使用两性霉素B开始患者静脉治疗和膀胱灌溉。患者在异戊酰肼上排出过6个月。

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