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Green synthesis of ibuprofen-nicotinamide cocrystals and in-line evaluation by Raman spectroscopy

机译：布洛芬-烟酰胺共晶体的绿色合成和拉曼光谱在线评估

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摘要

Pharmaceutical cocrystals are mixed crystals that contain two or more different molecular components. These crystals usually present different characteristics from their precursor, an improvement in the drug solubility being the most important property. This article is the first to report a green synthesis of ibuprofen-nicotinamide cocrystal in aqueous media. The use of safer solvents and in-line monitoring are some of the green chemistry principles that should be evaluated in environmentally correct synthesis. The Raman spectroscopy as a PAT tool provided an effective in line method to monitor and quantify the reaction. This is the first report of the cocrystal of ibuprofen-nicotinamide obtained by slurry conversion. A total conversion of the initial substrates into the cocrystal was obtained in mild conditions. The use of chemometric tools and Raman spectroscopy made it possible to monitor and understand the cocrystallization mechanism, and the synthesis provided.
机译：药物共晶体是包含两个或多个不同分子成分的混合晶体。这些晶体通常具有与其前体不同的特性，最重要的特性是药物溶解度的提高。本文是第一篇报道在水介质中绿色合成布洛芬-烟酰胺共晶体的文章。使用更安全的溶剂和进行在线监测是应在环境正确的合成过程中评估的一些绿色化学原理。拉曼光谱作为PAT工具提供了一种有效的在线方法来监测和定量反应。这是通过浆液转化获得布洛芬-烟酰胺共晶体的首次报道。在温和条件下获得了初始底物到共晶的总转化率。化学计量工具和拉曼光谱的使用使监测和了解共结晶机理以及所提供的合成成为可能。

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