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首页> 外文期刊>Acta Obstetricia et Gynecologica Scandinavica: Official Publication of the Nordisk Forening for Obstetrik och Gynekologi >HPV HPV ‐testing versus HPV HPV ‐cytology co‐testing to predict the outcome after conization
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HPV HPV ‐testing versus HPV HPV ‐cytology co‐testing to predict the outcome after conization

机译：HPV HPV -Testing与HPV HPV-Cytology Co-testing预测结束后的结果

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Abstract Introduction The purpose of this study was to determine the feasibility of human Papillomavirus ( HPV ) testing alone as a prognostic tool to predict recurrent disease within a three‐year follow‐up period after treatment for cervical intraepithelial neoplasia ( CIN )2 + . Material and methods Retrospectively, 128 women with histologically verified CIN 2 + who had a conization performed at Southern Jutland Hospital in Denmark between 1 January 2013 and 31 December 2013 were included. Histology, cytology and HPV test results were obtained for a three‐year follow‐up period. Results 4.7% (6/128) of the cases developed recurrent disease during follow‐up. Of the cases without free margins, recurrent dysplasia was detected normal in 10.4% (5/48), whereas in the group with free margins it was 1.3% (1/80). The post‐conization HPV test was negative in 67.2% (86/128) and Pap smear normal in 93.7% (120/128). Combining resection margins, cytology and HPV had sensitivity for prediction of recurrent dysplasia of 100%. Specificity was 45.8%, positive predictive value ( PPV ) 8.5% and negative predictive value ( NPV ) 100%. Using HPV test alone as a predictor of recurrent dysplasia gave a sensitivity of 83.3%, specificity 69.7%, PPV 11.9% and NPV 98.8%. Combining resection margin and HPV test had a sensitivity of 100%, specificity 45.9%, PPV 8.3% and NPV 100%. Conclusion HPV test at six months control post‐conization gave an NPV of 98.8% and can be used as a solitary test to identify women at risk for recurrent disease three years after treatment for precursor lesions. Using both resection margin and HPV test had a sensitivity of 100% and NPV 100%. Adding cytology did not increase the predictive value.
机译：摘要介绍本研究的目的是确定人乳头瘤病毒（HPV）测试的可行性单独作为预后工具，以预测治疗宫颈上皮内肿瘤（CIN）2 +后的三年后续时间内的复发性疾病。据包括，材料和方法回顾性，128名妇女在2013年1月1日至2013年12月31日在丹麦的南部Jutland医院进行了组织验证的CIN 2 +。组织学，细胞学和HPV测试结果是为期三年的随访期。结果4.7％（6/128）病例在随访期间发育了复发性疾病。在没有自由边缘的情况下，在10.4％（5/48）中检测到正常发生的发育不良，而在具有自由余量的组中，它为1.3％（1/80）。后锥后HPV试验在67.2％（86/128）中为阴性，PAP涂片正常为93.7％（120/128）。结合切除边缘，细胞学和HPV对预测到100％的经常性发育不良的敏感性。特异性为45.8％，阳性预测值（PPV）8.5％和负预测值（NPV）100％。单独使用HPV试验作为复发性发育不良的预测因子，敏感性为83.3％，特异性69.7％，PPV 11.9％和NPV 98.8％。结合切除裕度和HPV试验的敏感性为100％，特异性45.9％，PPV 8.3％和NPV 100％。结论HPV试验六个月控制后结束的NPV为98.8％，可用作孤独的检验，以鉴定前体病变治疗三年后的复发性疾病风险的妇女。使用切除率和HPV测试的灵敏度为100％和NPV 100％。添加细胞学没有增加预测值。

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