Molecular salts of anesthetic lidocaine with dicarboxylic acids: Solid-state properties and a combined structural and spectroscopic study

Braga D.; Chelazzi L.; Grepioni F.; Dichiarante E.; Chierotti M.R.; Gobetto R.

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Molecular salts of anesthetic lidocaine with dicarboxylic acids: Solid-state properties and a combined structural and spectroscopic study

机译：麻醉性利多卡因与二元羧酸的分子盐：固态性质以及组合的结构和光谱研究

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Four lidocaine molecular salts of dicarboxylic acids (oxalic, fumaric, malonic, and succinic) were synthesized and characterized by a combined use of X-ray powder and single-crystal diffraction, differential scanning calorimetry, Fourier transform infrared spectroscopy (FT-IR), and solid-state NMR (~1H MAS and CRAMPS, and ~(13)C and ~(15)N CPMAS): all molecular salts show a dramatic increase in their melting point with respect to both lidocaine and lidocaine hydrochloride, and a higher dissolution rate and thermodynamic solubility in physiological solution with respect to the free base.

机译：合成了四种利多卡因二羧酸（草酸，富马酸，丙二酸和琥珀酸）分子盐，并结合使用X射线粉末和单晶衍射，差示扫描量热法，傅里叶变换红外光谱（FT-IR）进行了表征，和固态NMR（〜1H MAS和CRAMPS，以及〜（13）C和〜（15）N CPMAS）：相对于利多卡因和盐酸利多卡因，所有分子盐均显示出熔点的急剧升高，并且更高相对于游离碱在生理溶液中的溶解速率和热力学溶解度。

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《Crystal growth & design》 |2013年第6期|共9页
作者
Braga D.; Chelazzi L.; Grepioni F.; Dichiarante E.; Chierotti M.R.; Gobetto R.;
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正文语种 eng
中图分类晶体学;
关键词
anesthetic lidocaine; dicarboxylic acids; spectroscopic study;

机译：麻醉剂利多卡因;二羧酸;光谱学研究;

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1. Molecular salts of anesthetic lidocaine with dicarboxylic acids: Solid-state properties and a combined structural and spectroscopic study [J] . Braga D., Chelazzi L., Grepioni F., Crystal growth & design . 2013,第6期

机译：麻醉性利多卡因与二元羧酸的分子盐：固态性质以及组合的结构和光谱研究
2. Spectroscopic, Structural, DFT and Molecular Docking Studies on Novel Cocrystal Salt Hydrate of Chromotropic Acid and Its Antibiofilm Activity [J] . Syed Sibte Asghar Abidi, Utsav Garg, Yasser Azim, Arabian Journal for Science and Engineering. Section A, Sciences . 2021,第1期

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3. Structural, spectral and thermal properties of a supramolecular assembly based on p-phenylenediamine and trichloroacetic acid: A combined experimental and computational study [J] . Ouannassi F., Berrah F., Boursas F., Journal of Molecular Structure . 2021,第1期

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4. Novel Thermoplastic Copolyamides Based on Caprolactam, 1,6 - Hexane Diamine and Dicarboxylic Acids. Synthesis and Study of Properties [C] . Zanoaga Madalina 12th Romanian International Conference on Chemistry and Chemical Engineering, Sep 13-15, 2001, Bucharest, Romania . 2001

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5. Nuclear Magnetic Resonance Studies of Dynamical Structure of One-Dimensional Hydrogen-Bonded System in the Acid Salts of Some Dicarboxylic Acids [D] . 宮久保, 圭祐 1994

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6. Molecular Crystal Forms of Antitubercular Ethionamide with Dicarboxylic Acids: Solid-State Properties and a Combined Structural and Spectroscopic Study [O] . Simone Bordignon, Paolo Cerreia Vioglio, Elena Amadio, 2020

机译：用二羧酸的抗细胞乙醇的分子晶体形式：固态性质和组合结构和光谱研究
7. Molecular Crystal Forms of Antitubercular Ethionamide with Dicarboxylic Acids: Solid-State Properties and a Combined Structural and Spectroscopic Study [O] . Simone Bordignon, Paolo Cerreia Vioglio, Elena Amadio, 2020

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8. Ultraviolet Photoelectron Spectroscopic Studies of Dicarboxylic Acids and Phosphorus Compounds [R] . Chattopadhyay, S. K. 1979

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Molecular salts of anesthetic lidocaine with dicarboxylic acids: Solid-state properties and a combined structural and spectroscopic study

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