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首页> 外文期刊>Acta veterinaria. >INFLUENCE OF SEVOFLURANE OR PROPOFOL ANAESTHESIA ON OXIDATIVE STRESS PARAMETERS IN DOGS WITH EARLY-STAGE MYXOMATOUS MITRAL VALVE DEGENERATION. A PRELIMINARY STUDY
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INFLUENCE OF SEVOFLURANE OR PROPOFOL ANAESTHESIA ON OXIDATIVE STRESS PARAMETERS IN DOGS WITH EARLY-STAGE MYXOMATOUS MITRAL VALVE DEGENERATION. A PRELIMINARY STUDY

机译：七氟烷或异丙酚麻醉对早期近期近期乳腺二尖瓣变性犬氧化应激参数的影响。 初步研究

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摘要

The aim of this study was to investigate the effects of total intravenous anaesthesia with propofol and anaesthesia induced with propofol and maintained with sevoflurane on oxidative stress parameters in dogs with early-stage myxomatous mitral valve degeneration (MMVD). Sixteen client-owned dogs with early stage MMVD that required periodontal treatment were included in the study. After induction with propofol, anaesthesia was maintained with propofol (group P) or sevoflurane (group PS). Blood samples for determination of vitamin E, superoxide dismutase, glutathione peroxidase and malondialdehyde were collected before premedication, 5 and 60 minutes and 6 hours after induction to anaesthesia. There were no significant differences between groups in any of the oxidative stress parameters at each sampling time. Compared to basal values, vitamin E concentration decreased significantly during anaesthesia in both groups and glutathione peroxidase activity increased 60 minutes after induction to anaesthesia in PS group. Anaesthesia with propofol or with propofol and sevoflurane did not have any significant impact on oxidative stress parameters in dogs with early stage MMVD. In terms of oxidative stress, both protocols may be equally safely used in dogs with early stage MMVD.
机译：本研究的目的是探讨总静脉内麻醉与用异丙酚和用异丙酚诱导的麻醉的影响，并用七氟醚对具有早期近期乳糜磷酸二尖瓣变性（MMVD）的狗的氧化应激参数。具有早期MMVD的十六个客户拥有的狗，需要牙周治疗。用异丙酚诱导后，用异丙酚（P组）或七氟醚（基团PS）保持麻醉。在预诊断之前收集用于测定维生素E，超氧化物歧化酶，谷胱甘肽过氧化物酶和丙二醛的血液样品。每个采样时间的任何氧化应激参数中的组之间没有显着差异。与基础值相比，维生素E浓度在麻醉时在麻醉时显着降低，并且谷胱甘肽过氧化物酶活性在PS组诱导后60分钟增加。用异丙酚或六氟醚的麻醉对具有早期MMVD的狗的氧化应激参数没有任何显着影响。就氧化应激而言，两种方案可以在具有早期MMVD的狗中安全使用。

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