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首页> 外文期刊>Acta Biochimica Polonica >Gamijeonssibaekchulsan regulates mast cell-mediated anaphylactic reaction
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Gamijeonssibaekchulsan regulates mast cell-mediated anaphylactic reaction

机译：Gamijeonssibaekchulsan调节肥大细胞介导的过敏反应

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摘要

Gamijeonssibaekchulsan (GJBS) is a typical Oriental medicine prescription which has been used in Korea for the treatment of allergic diseases and the development of physical strength. However, as yet there is no clear explanation of how GJBS affects the anaphylactic reaction and the immune function. In the present study murine models and MOLT-4 cells, a T cell line, were used to investigate these effects. Compound 48/80-induced systemic anaphylactic shock and ear swelling response were firstly analyzed. We also assayed histamine release and passive cutaneous anaphylaxis (PCA) in mice and cytokine productions in MOLT-4 cells. GJBS significantly inhibits compound 48/80-induced systemic anaphylactic shock and ear swelling response. GJBS also inhibits histamine release from rat peritoneal mast cells induced by compound 48/80. PCA activated by anti-dinitrophenyl immunoglobulin E is attenuated by GJBS. However, GJBS dose not affect the production of interferon-gamma, interleukin (IL)-2, and IL-4 in MOLT-4 cells. These results indicate that GJBS has a potential regulatory effect on allergic reactions that are mediated by mast cells.
机译：Gamijeonssibaekchulsan（GJBS）是一种典型的东方医学处方，已在韩国用于治疗过敏性疾病和增强体力。然而，关于GJBS如何影响过敏反应和免疫功能尚无明确的解释。在本研究中，鼠模型和MOLT-4细胞（一种T细胞系）用于研究这些作用。首先分析了化合物48/80引起的全身过敏性休克和耳肿胀反应。我们还分析了小鼠中的组胺释放和被动皮肤过敏反应（PCA），以及MOLT-4细胞中的细胞因子产生。 GJBS显着抑制化合物48/80引起的全身过敏性休克和耳肿胀反应。 GJBS还抑制由化合物48/80诱导的大鼠腹膜肥大细胞中的组胺释放。抗二硝基苯基免疫球蛋白E激活的PCA被GJBS减弱。但是，GJBS不会影响MOLT-4细胞中干扰素-γ，白介素（IL）-2和IL-4的产生。这些结果表明，GJBS对肥大细胞介导的过敏反应具有潜在的调节作用。

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