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Physical and chemical profiles of nanoparticles for lymphatic targeting

机译：纳米粒子的物理和化学分布用于淋巴靶向

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摘要

Nanoparticles (NPs) have been gaining prominence as delivery vehicles for modulating immune responses to improve treatments against cancer and autoimmune diseases, enhancing tissue regeneration capacity, and potentiating vaccination efficacy. Various engineering approaches have been extensively explored to control the NP physical and chemical properties including particle size, shape, surface charge, hydrophobicity, rigidity and surface targeting ligands to modulate immune responses. This review examines a specific set of physical and chemical characteristics of NPs that enable efficient delivery targeted to secondary lymphoid tissues, specifically the lymph nodes and immune cells. A critical analysis of the structure-property-function relationship will facilitate further efforts to engineer new NPs with unique functionalities, identify novel utilities, and improve the clinical translation of NP formulations for immunotherapy.
机译：纳米颗粒（NPS）一直在突出作为调节免疫反应的递送载体，以改善针对癌症和自身免疫疾病的治疗，提高组织再生能力和增强疫苗接种功效。 已经广泛探索了各种工程方法以控制NP物理和化学性质，包括粒度，形状，表面电荷，疏水性，刚性和表面靶向配体以调节免疫应答。 本综述检测NPS的特定物理和化学特征，使靶向次级淋巴组织的有效递送，特别是淋巴结和免疫细胞。 对结构 - 财产功能关系的批判性分析将有助于进一步努力以独特的功能，识别新颖的公用事业，并改善NP配方免疫疗法的临床翻译。

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