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首页> 外文期刊>Acta Biochimica Polonica >Different statins produce highly divergent changes in gene expression profiles of human hepatoma cells: A pilot study
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Different statins produce highly divergent changes in gene expression profiles of human hepatoma cells: A pilot study

机译：初步研究表明，不同的他汀类药物在人肝癌细胞的基因表达谱中产生高度不同的变化

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摘要

Statins are inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR), the key enzyme of the sterol biosynthesis pathway. Statin therapy is commonly regarded as well tolerated. However, serious adverse effects have also been reported, especially during high-dose statin therapy. The aim of our study was to investigate the effect of statins on gene expression profiles in human hepatoma HepG2 cells using Affymetrix Human Genome U133 Plus 2.0 arrays. Expression of 102, 857 and 1091 genes was changed substantially in HepG2 cells treated with simvastatin, fluvastatin and atorvastatin, respectively. Pathway and gene ontology analysis showed that many of the genes with changed expression levels were involved in a broad range of metabolic processes. The presented data clearly indicate substantial differences between the tested statins.
机译：他汀类药物是3-羟基-3-甲基戊二酰辅酶A还原酶（HMGR）的抑制剂，HMGR是固醇生物合成途径的关键酶。通常认为他汀类药物的耐受性良好。但是，也已经报道了严重的不良反应，尤其是在大剂量他汀类药物治疗期间。我们研究的目的是使用Affymetrix Human Genome U133 Plus 2.0阵列研究他汀类药物对人肝癌HepG2细胞基因表达谱的影响。在分别用辛伐他汀，氟伐他汀和阿托伐他汀处理的HepG2细胞中，102、857和1091基因的表达发生了实质性变化。途径和基因本体分析表明，许多表达水平改变的基因都参与了广泛的代谢过程。呈现的数据清楚地表明了所测试的他汀类药物之间的实质性差异。

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