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首页> 外文期刊>Acta Radiologica >Diffusional kurtosis imaging of kidneys in patients with hyperuricemia: initial study
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Diffusional kurtosis imaging of kidneys in patients with hyperuricemia: initial study

机译：高尿酸血症患者肾脏扩散峰脉状成像：初步研究

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Background At present, there remains a lack of a reliable indicator for monitoring renal function in patients with hyperuricemia. Purpose This study aimed to evaluate the feasibility of diffusion kurtosis imaging in the assessment of renal function in patients with hyperuricemia. Material and Methods A total of 75 male participants, including 25 with asymptomatic hyperuricemia, 25 with gouty arthritis, and 25 age-matched male healthy controls, were enrolled in this study. Diffusion kurtosis imaging data were acquired to derive axial (Ka), radial (Kr), and mean kurtosis (MK), fractional anisotropy, axial (Da), radial (Dr), and mean diffusivity (MD) for comparisons among the three groups. They were also correlated with estimated glomerular filtration rate (eGFR). Results The MK values of the renal cortex and medulla and Kr value of the renal medulla in patients with asymptomatic hyperuricemia and gouty arthritis significantly increased compared with those in the controls (P < 0.05). Patients with gouty arthritis showed significant higher cortical and medullary Ka values compared with the other two groups (P < 0.05). The cortical Kr values of the asymptomatic hyperuricemia and gouty arthritis patients were significantly higher than that of the controls (P < 0.05). The medullary fractional anisotropy value showed a significant difference between the control and gouty arthritis groups (P < 0.05). No correlation was found between any diffusion kurtosis imaging parameters and eGFR value. Conclusion Diffusion kurtosis imaging is feasible in the assessment of the early changes of renal cortex and medulla in patients with hyperuricemia.
机译：背景目前，仍然缺乏可靠的指标，用于监测高尿酸血症患者的肾功能。目的本研究旨在评估扩散刚性病变成像在高尿酸血症患者肾功能评估中的可行性。材料和方法共有75名雄性参与者，其中25例，伴有痛风性关节炎，25例，25例年龄匹配的男性健康对照，在本研究中注册。获取扩散kurtosis成像数据以导出轴向（Ka），径向（KR）和平均峰（MK），分数各向异性，轴向（DA），径向（DR）和平均扩散性（MD），以便在三组中进行比较。它们也与估计的肾小球过滤速率（EGFR）相关。结果无症状高尿酸血症患者肾皮质和髓质髓质髓质和KR值的MK值与对照组相比，肾髓质和痛风性关节炎相比显着增加（P <0.05）。与其他两组相比，痛风关节炎患者显示出显着的皮质和髓质Ka值（P <0.05）。无症状高温血症和痛风性关节炎患者的皮质KR值显着高于对照（P <0.05）。髓质分数各向异性值显示对照和痛风性关节炎基团之间存在显着差异（P <0.05）。在任何扩散kurtosis成像参数和EGFR值之间没有发现相关性。结论扩散峰穴成像在高尿酸血症患者肾皮质和髓质的早期变化中是可行的。

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