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首页> 外文期刊>Acta Radiologica >Altered brain network centrality in patients with trigeminal neuralgia: a resting-state fMRI study
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Altered brain network centrality in patients with trigeminal neuralgia: a resting-state fMRI study

机译：三叉神经痛患者的大脑网络中心改变：休息状态FMRI研究

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摘要

Background Neuroimaging studies revealed that trigeminal neuralgia was related to alternations in brain anatomical function and regional function. However, the functional characteristics of network organization in the whole brain is unknown. Purpose The aim of the present study was to analyze potential functional network brain-activity changes and their relationships with clinical features in patients with trigeminal neuralgia via the voxel-wise degree centrality method. Material and Methods This study involved a total of 28 trigeminal neuralgia patients (12 men, 16 women) and 28 healthy controls matched in sex, age, and education. Spontaneous brain activity was evaluated by degree centrality. Correlation analysis was used to examine the correlations between behavioral performance and average degree centrality values in several brain regions. Results Compared with healthy controls, trigeminal neuralgia patients had significantly higher degree centrality values in the right lingual gyrus, right postcentral gyrus, left paracentral lobule, and bilateral inferior cerebellum. Receiver operative characteristic curve analysis of each brain region confirmed excellent accuracy of the areas under the curve. There was a positive correlation between the mean degree centrality value of the right postcentral gyrus and VAS score (r = 0.885, P < 0.001). Conclusions Trigeminal neuralgia causes abnormal brain network activity in multiple brain regions, which may be related to underlying disease mechanisms.
机译：背景技术神经影像学研究表明，三叉神经痛与脑解剖功能和区域功能的替换有关。然而，整个大脑中网络组织的功能特征是未知的。目的本研究的目的是分析潜在的功能性网络脑活动变化及其与通过体素 - 明度中心度的三叉神经痛患者的临床特征的关系。材料和方法本研究涉及共有28名三叉神经痛患者（12名男性，16名女性）和28名健康对照，在性别，年龄和教育中匹配。自发性脑活动是通过程度的中心评估的。相关性分析用于检查几种脑区行为性能与平均中心值之间的相关性。结果与健康对照相比，三叉神经痛患者在右侧舌型转象，右侧中央回雷斯，左侧面向鳞茎和双侧劣质小脑中具有明显较高的程度的中心值。每个脑区域的接收器操作特征曲线分析确认了曲线下区域的优异精度。右侧中间体过度的平均中心值与VAS得分（r = 0.885，p <0.001）之间存在正相关性之间的正相关性。结论三叉神经痛导致多脑地区的异常脑网络活动，这可能与潜在的疾病机制有关。

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  • 来源
    《Acta Radiologica》 |2020年第1期|共9页
  • 作者

    Zhu Pei-Wen; Chen You; Gong Ying-Xin; Jiang Nan; Liu Wen-Feng; Su Ting; Ye Lei; Min You-Lan; Yuan Qing; He Lai-Chang; Shao Yi;

  • 作者单位

    Nanchang Univ Dept Ophthalmol Affiliated Hosp 1 17 YongWaiZheng St Nanchang 330006 Jiangxi;

    Nanchang Univ Dept Radiol Affiliated Hosp 1 Nanchang Jiangxi Peoples R China;

    Nanchang Univ Dept Ophthalmol Affiliated Hosp 1 17 YongWaiZheng St Nanchang 330006 Jiangxi;

    Xiamen Univ Fujian Prov Key Lab Ophthalmol &

    Visual Sci Eye Inst Xiamen Fujian Peoples R China;

    Nanchang Univ Dept Ophthalmol Affiliated Hosp 1 17 YongWaiZheng St Nanchang 330006 Jiangxi;

    Xiamen Univ Fujian Prov Key Lab Ophthalmol &

    Visual Sci Eye Inst Xiamen Fujian Peoples R China;

    Nanchang Univ Dept Ophthalmol Affiliated Hosp 1 17 YongWaiZheng St Nanchang 330006 Jiangxi;

    Nanchang Univ Dept Ophthalmol Affiliated Hosp 1 17 YongWaiZheng St Nanchang 330006 Jiangxi;

    Nanchang Univ Dept Ophthalmol Affiliated Hosp 1 17 YongWaiZheng St Nanchang 330006 Jiangxi;

    Nanchang Univ Dept Radiol Affiliated Hosp 1 Nanchang Jiangxi Peoples R China;

    Nanchang Univ Dept Ophthalmol Affiliated Hosp 1 17 YongWaiZheng St Nanchang 330006 Jiangxi;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 放射医学;
  • 关键词

    Trigeminal neuralgia; voxel-wise degree centrality; brain activity changes;

    机译：三叉神经痛;体素 - 明智的度数;脑活动变化;

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