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Bone-Adhesive Materials: Clinical Requirements, Mechanisms of Action, and Future Perspective

机译：骨胶材料：临床要求，行动机制和未来的观点

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摘要

Each year, millions of people suffer from complex bone fractures which require proper external or internal fixation. This fixation is usually achieved by means of devices such as plates, pins, and screws. These traditional fixation strategies are associated with severe drawbacks, which have prompted research and development of a variety of bone-adhesive biomaterials as alternative. However, a clinically applicable bone-adhesive biomaterial-in the form of a bone-glue or bone-adhesive membrane-that meets all requirements has not yet been identified. This perspective article discusses the current state of the art of bone-adhesive materials with a particular focus on their clinical requirements, mechanisms of action, and future perspective. To develop adhesive biomaterials with specific affinity to bone tissue, a more rational design should be implemented. This perspective article is intended as a starting point and inspiration for future research and development of suitable bone-adhesive materials.
机译：每年，数百万人患有复杂的骨折，需要适当的外部或内部固定。这种固定通常通过诸如板，销和螺钉等装置来实现。这些传统的固定策略与严重的缺点有关，促使各种骨粘性生物材料的研究和开发作为替代方案。然而，尚未确定含有骨胶或骨粘合剂膜的临床适用的骨粘性生物材料 - 含有骨胶或骨粘合剂膜的形式。该透视文章讨论了骨粘性材料领域的现状，特别关注其临床要求，行动机制和未来的观点。为了开发具有特异性亲和力对骨组织的粘合性生物材料，应实施更合理的设计。这个透视文章旨在作为适合合适的骨胶材料的研究和开发的起点和灵感。

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