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Automation and Experience of Controlled Crystal Dehydration: Results from the European Synchrotron HC1 Collaboration

机译：自动化和受控晶体脱水的经验：欧洲同步加速器HC1合作的结果

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Controlled dehydration of macromolecular crystals can lead to significant improvements in crystalline order, which often manifests itself in higher diffraction quality. Devices that can accurately control the humidity surrounding crystals on a beamline have led to this technique being increasingly adopted as experiments become easier and more reproducible. However, these experiments are often carried out by trial and error, and in order to facilitate and streamline them four European synchrotrons have established a collaboration around the HC1b dehydration device. The MAX IV Laboratory, Diamond Light Source, BESSY II, and the EMBL Grenoble Outstation/ESRF have pooled information gathered from user experiments, and on the use of the device, to propose a set of guidelines for these experiments. Here, we present the status and automation of the installations, advice on how best to perform experiments using the device, and an analysis of successful experiments that begins to show some trends in the type of protocols required by some systems. The dehydration methods shown are applicable to any device that allows control of the relative humidity of the air surrounding a macromolecular crystal.
机译：大分子晶体的受控脱水可导致晶体顺序的显着改善，这通常表现为更高的衍射质量。可以精确控制光束线上晶体湿度的设备已导致随着实验变得更容易，更可重现而越来越多地采用该技术。但是，这些实验通常是通过反复试验来进行的，为了促进和简化它们，四个欧洲同步加速器围绕HC1b脱水装置建立了合作关系。 MAX IV实验室，Diamond Light Source，BESSY II和EMBL Grenoble Outstation / ESRF收集了从用户实验中收集到的信息以及有关设备的使用情况，从而为这些实验提出了一套指南。在这里，我们介绍了设备的状态和自动化，有关如何最好地使用设备执行实验的建议以及对成功实验的分析，这些实验开始显示某些系统所需协议类型的一些趋势。所示的脱水方法适用于任何可控制大分子晶体周围空气相对湿度的装置。

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