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首页> 外文期刊>Addiction biology >Cannabidiol reduces ethanol consumption, motivation and relapse in mice
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Cannabidiol reduces ethanol consumption, motivation and relapse in mice

机译：大麻减少小鼠的乙醇消费，动机和复发

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Abstract This study evaluated the effects of cannabidiol (CBD) on ethanol reinforcement, motivation and relapse in C57BL/6 J mice. The effects of CBD (60 mg/kg, i.p.) on blood ethanol concentration, hypothermia and handling‐induced convulsions associated to acute ethanol administration were evaluated. The two‐bottle choice paradigm was performed to assess the effects of CBD (30, 60 and 120 mg/kg/day, i.p.) on ethanol intake and preference. In addition, an oral ethanol self‐administration experiment was carried out to evaluate the effects of CBD [a single s.c. administration of a microparticle formulation providing CBD continuous controlled release (30 mg/kg/day)] on the reinforcement and motivation for ethanol. The effects of CBD (60 and 120 mg/kg/day, i.p.) on ethanol‐induced relapse were also evaluated. Gene expression analyses of tyrosine hydroxylase in ventral tegmental area and μ‐opioid (Oprm1), cannabinoid (CB 1 r and CB 2 r) and GPR55 receptors in nucleus accumbens (NAcc) were carried out by real‐time polymerase chain reaction. Cannabidiol reduced the ethanol‐induced hypothermia and handling‐induced convulsion but failed to modify blood ethanol concentration. CBD reduced ethanol consumption and preference in the two‐bottle choice, significantly decreased ethanol intake and the number of effective responses in the oral ethanol self‐administration, and reduced ethanol‐induced relapse. Furthermore, the administration of CBD significantly reduced relative gene expression of tyrosine hydroxylase in the ventral tegmental area, Oprm1, CB 1 r and GPR55 in the NAcc and significantly increased CB 2 r in the NAcc. Taken together, these results reveal that the administration of CBD reduced the reinforcing properties, motivation and relapse for ethanol. These findings strongly suggest that CBD may result useful for the treatment of alcohol use disorders.
机译：摘要本研究评估了大麻（CBD）对C57BL / 6 J小鼠乙醇增强，动机和复发的影响。评价CBD（60mg / kg，i.p.）对血液乙醇浓度，低温和处理诱导的与急性乙醇给药相关的痉挛的影响。进行双瓶选择范式以评估CBD（30,60和120mg / kg /天，I.P.）对乙醇摄入和偏好的影响。此外，进行口服乙醇自我管理实验，以评估CBD的作用[单个S.C.施用微粒制剂，提供CBD连续控制释放（30mg / kg /天）的增强和激活乙醇。还评估了CBD（60和120mg / kg /天，I.p.）对乙醇诱导的复发的影响。通过实时聚合酶链式反应进行腹侧脑面积和μ-ApiOID（OPRM1），大麻素（IPRM1），大麻素（CB 1 R和CB 2 R）和GPR55受体的基因表达分析，大麻素（CB 1 R和CB 2 R）和GPR55受体进行。大麻诱导的乙醇诱导的低温和处理诱导的痉挛，但未改变血液乙醇浓度。 CBD在双瓶选择中降低了乙醇消耗和偏好，显着降低了乙醇摄入量和口服乙醇自我给药中有效反应的数量，降低了乙醇诱导的复发。此外，在NACC中，在NACC中的腹侧羟化物区域，OPRM1，CB 1 R和GPR55中的酪氨酸羟化酶的相对基因表达显着降低了酪氨酸羟化酶的相对基因表达，并在NACC中显着增加了CB 2 R。总之，这些结果表明，CBD的给药降低了乙醇的增强性能，动机和复发。这些发现强烈表明CBD可能导致治疗酒精使用障碍有用。

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