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首页> 外文期刊>Crystal growth & design >A New Method for Producing Pharmaceutical Co-crystals: Laser Irradiation of Powder Blends
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A New Method for Producing Pharmaceutical Co-crystals: Laser Irradiation of Powder Blends

机译：制备药物共晶体的新方法：粉末共混物的激光辐照

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In this work, a high-power CO2 laser was used to irradiate powder blends of co-crystal formers, with the specific aim of trying to cause recrystallization to a co-crystal structure. By varying the :power and raster speed of the laser, it was found that sufficient thermal energy could be imparted to the powder to cause molecular rearrangement. It was possible to form co-crystals of caffeine with oxalic acid and caffeine with malonic acid. Interestingly, it was found that, to form co-crystals successfully, the coformers needed to sublime to an appreciable extent, which indicates that the mechanism of rearrangement involves interaction and nucleation in the vapor phase. Laser irradiation thus offers a new route to creation of pharmaceutical, co-crystals and a potentially rapid screen for likely co-crystal formation between coforming pairs.
机译：在这项工作中，使用大功率的CO2激光照射共晶形成剂的粉末混合物，其特定目的是试图使重结晶为共晶结构。通过改变激光的功率和光栅速度，发现可以将足够的热能赋予粉末以引起分子重排。咖啡因与草酸和咖啡因与丙二酸的共晶体是可能的。有趣的是，已经发现，为了成功地形成共晶体，共形成剂需要升华到一定程度，这表明重排的机理涉及气相中的相互作用和成核作用。因此，激光辐照提供了一条新的途径来制造药物，共晶体，并为在共成形对之间可能形成共晶体提供了可能的快速筛选。

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