...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Crystal growth & design >Interactions of antithyroid drugs and their analogues with halogens and their biological implications
【24h】

Interactions of antithyroid drugs and their analogues with halogens and their biological implications

机译：抗甲状腺药物及其类似物与卤素的相互作用及其生物学意义

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The selenium analogue of antithyroid drug methimazole (MSeI) reacts with molecular bromine to produce two different types of novel complexes depending upon the molar ratio of MSeI to Br_2 in the reaction medium. Dicationic diselenide complex with two Br-ions as counterions is produced in the reaction of MSeI with 0.5 equiv of Br_2 (MSeI/Br _2, 1.0:0.5), whereas a stable 10-Se-3 hypervalent "T-shaped" complex featuring a linear Br-Se-Br moiety was produced when MSeI was treated with Br_2 in an equimolar ratio (MSeI/Br _2, 1.0:1.0). A substitution at the free N-H group in MSeI alters its reactivity toward iodine/bromine. For example, the N,N-disubstituted selones exclusively produce the corresponding 10-Se-3 hypervalent "T-shaped" complexes in the reaction with I_2. In the presence of the lectoperoxidase/H_2O_2/I~- system, N,N-dimethylimidazole-2-selone produces the corresponding dicationic diselenide with two I- counterions as the final metabolite. The formation of ionic species in these reactions is confirmed by single crystal X-ray diffraction studies and in some cases by Fourier transform-Raman spectroscopic investigations.
机译：取决于反应介质中MSeI与Br_2的摩尔比，抗甲状腺药Methimazole（MSeI）的硒类似物与分子溴反应生成两种不同类型的新型配合物。 MSeI与0.5当量的Br_2（MSeI / Br _2，1.0：0.5）反应生成带有两个Br离子作为抗衡离子的二阳离子二硒化物配合物，而稳定的10-Se-3高价“ T形”配合物具有当用等摩尔比（MSeI / Br _2，1.0：1.0）的Br_2处理MSeI时，产生线性Br-Se-Br部分。 MSeI中游离N-H基团的取代会改变其对碘/溴的反应性。例如，在与I_2的反应中，N，N-二取代的丝氨酸仅产生相应的10-Se-3高价“ T形”复合物。在存在过氧化物酶/ H_2O_2 / I-系统的情况下，N，N-二甲基咪唑-2-硒酮生成相应的二硒代二硒化物，其中两个I-抗衡离子为最终代谢产物。这些反应中离子种类的形成已通过单晶X射线衍射研究得以证实，在某些情况下，已通过傅里叶变换拉曼光谱研究得以证实。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号