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首页> 外文期刊>AIDS care. >Reconciling the evaluation of co-morbidities among HIV care patients in two large data systems: the Medical Monitoring Project and CFAR Network of Integrated Clinical Systems
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Reconciling the evaluation of co-morbidities among HIV care patients in two large data systems: the Medical Monitoring Project and CFAR Network of Integrated Clinical Systems

机译：在两个大型数据系统中调整艾滋病毒护理患者共生体的评估：综合临床系统的医学监测项目和CFAR网络

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The estimated burden of chronic disease among people living with HIV (PLWH) varies considerably by data source, due to differences in case definitions, analytic approaches, and underlying patient populations. We evaluated the burden of diabetes (DM) and chronic kidney disease (CKD) in two large data systems that are commonly queried to evaluate health issues affecting HIV care patients: the Medical Monitoring Project (MMP), a nationally representative sample, and the Centers for AIDS Research Network of Integrated Clinical Systems (CNICS), a clinical cohort. In order to reconcile these two data sources, we addressed issues common to observational data, including selection bias, missing data, and development of case definitions. The overall adjusted estimated prevalence of DM and CKD in MMP was 12.7% and 7.6%, respectively, and the overall prevalence of DM and CKD in CNICS was 9.9% and 8.3%, respectively; prevalence estimates increased with age in both data sources. After reconciling the approach to analyzing MMP and CNICS data, sub-group specific prevalence estimates of DM and CKD was generally similar in both data sources. Both data sources suggest a considerable burden of disease among older adults in HIV care. MMP and CNICS can provide reliable data to monitor HIV co-morbidities in the US.
机译：由于病例定义，分析方法和潜在患者人口的差异，患有艾滋病毒（PLWH）的人们患有艾滋病毒（PLWH）的慢性疾病的估计负担因数据来源而变化。我们评估了两种大型数据系统中糖尿病（DM）和慢性肾病（CKD）的负担，通常询问影响艾滋病毒护理患者的健康问题：医疗监测项目（MMP），国家代表性样本和中心艾滋病研究网络综合临床系统（CNICS），临床队列。为了协调这两个数据来源，我们解决了对观察数据共同的问题，包括选择偏差，缺失数据以及案例定义的开发。 MMP中DM和CKD的总体调整后的估计流行分别为12.7％和7.6％，CNIC中DM和CKD的总体流行分别为9.9％和8.3％;普及估计随着数据来源的年龄而增加。在协调分析MMP和CNICS数据的方法之后，DM和CKD的子组特定流行估计在两个数据源中通常相似。两个数据来源都表明艾滋病毒护理中老年人的大量疾病负担。 MMP和CNIC可以提供可靠的数据来监测美国的艾滋病毒共同病态。

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