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首页> 外文期刊>AIDS Research and Human Retroviruses >Immune Correlates of Herpes Zoster in People Living with HIV on Effective Antiretroviral Therapy
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Immune Correlates of Herpes Zoster in People Living with HIV on Effective Antiretroviral Therapy

机译：患有艾滋病毒患者艾滋病毒抗逆转录病毒治疗的人群的免疫相关性

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Herpes zoster (HZ) has high morbidity in people living with HIV (PLHIV). We investigated immunological factors that correlated with the development of HZ in PLHIV with controlled HIV replication on antiretroviral therapy (ART). PLHIV who developed HZ on ART (cases), with undetectable plasma HIV RNA, and CD4 counts >= 200 cells/mu L were matched 1:1 to controls by CD4 count, age, gender, race, and duration of ART. Varicella-zoster virus (VZV)-specific T cells and circulating regulatory T cells (Treg) were measured by flow cytometry before and after HZ. Differences between cases and controls were assessed by paired t-tests and longitudinal changes by Wilcoxon signed rank test. HZ cases (N = 31) had higher CD4(+)FOXP3(+)CD25(+)% Treg before HZ compared with 31 controls. After VZV ex vivo restimulation, cases had lower T cell responses, including CD8(+)perforin(+)% cytotoxic T lymphocytes (CTLs), CD4(+)IL10(+)%, and CD4(+)TGF beta(+)% compared with controls. Overall, Treg negatively correlated with VZV-specific Th1 responses. Moreover, Treg decreased over time on ART in HZ cases, VZV-CTLs were stable and did not increase even after HZ. Increased circulating Treg and decreased VZV-specific T cell immune responses were associated with the risk of HZ in PLHIV. The kinetics of Treg over time, but not of VZV-CTLs, paralleled the natural history of HZ, whose incidence decreases over time on effective ART.
机译：疱疹围疱疹（Hz）对艾滋病毒（Plhiv）的人具有高发病率。我们调查了与抗逆转录病毒治疗（ART）对艾滋病毒复制的PLHIV中Hz的发育相关的免疫因素。通过CD4计数，年龄，性别，种族和艺术持续量匹配1：1对照组术语（案例）的HZ和CD4计数> = 200个细胞/μl。通过在Hz之前和之后通过流式细胞术测量Varicella-Zoster病毒（VZV）的特异性T细胞和循环调节T细胞（Treg）。通过Wilcoxon签名等级试验对患者和对照之间的差异进行评估和纵向变化。 Hz案例（n = 31）在Hz之前具有更高的CD4（+）Foxp3（+）CD25（+）％Treg与31例对照。在VZV前体内重新刺激之后，病例具有较低的T细胞应答，包括CD8（+）穿孔素（+）％细胞毒性T淋巴细胞（CTL），CD4（+）IL10（+）％和CD4（+）TGFβ（+） ％与对照相比。总体而言，Treg与特定于VZV的TH1反应呈负相关。此外，在Hz案例中，Treg随着时间的推移而减少，VZV-CTL均稳定，甚至在Hz之后也没有增加。增加循环Treg和降低的VZV特异性T细胞免疫应答与PLHIV中Hz的风险有关。 Treg的动力学随着时间的推移，但不是VZV-CTL，并不平行于Hz的自然历史，其发病率随着时间的推移而减少。

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