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首页> 外文期刊>AIDS Research and Human Retroviruses >HIV DNA Measurement and Improved Detection of HIV Infection Among Men Who Have Sex with Men: A Strategic Implication
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HIV DNA Measurement and Improved Detection of HIV Infection Among Men Who Have Sex with Men: A Strategic Implication

机译：HIV DNA测量和改善与男性发生性关系的男性艾滋病毒感染的检测：战略意义

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摘要

Rapid test (RT) is the principal screening method in the HIV control practice. However, this method may lead to inaccurate detection, primarily due to the more than 4 weeks of window phase. In the present study, we performed a HIV DNA screening method to show its application prospects in men who have sex with men (MSM). From July 2017 to April 2018, we recruited 1,301 MSM from Beijing who were not previously diagnosed as HIV positive. Both HIV DNA detection and RT were performed. In total, 141 and 135 HIV-positive results were detected by DNA detection and RT, respectively. By repetitive and confirmative tests (Western blot), we verified that DNA detection detected 10 more true positives than RT and 4 false positives were corrected from RT. This represents 14 inaccurate RT results that were corrected by DNA measurement. Therefore, DNA measurement should be fully considered as a screening method in the detection of HIV among MSM in the future.
机译：快速试验（RT）是艾滋病毒控制实践中的主要筛选方法。 然而，这种方法可能导致检测不准确，主要是由于窗阶段超过4周。 在本研究中，我们进行了HIV DNA筛查方法，以表明其与男性发生性关系的男性的应用前景（MSM）。 从2017年7月至2018年4月，我们从北京招募了1,301名MSM，他们之前未被诊断为艾滋病毒阳性。 进行HIV DNA检测和室温。 总共，通过DNA检测和室温检测141和135个HIV阳性结果。 通过重复和确认的测试（Western Blot），我们验证了DNA检测检测到的10种真正的阳性比RT，4个假阳性从RT纠正。 这表示14个不准确的RT结果，其通过DNA测量校正。 因此，DNA测量应被完全被认为是未来MSM中检测艾滋病毒的筛选方法。

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  • 作者

    Chen Kai; Wang Yuehua; He Xiaoxia; Yao Jun; Xia Dongyan; Lu Hongyan; Jiang Yan;

  • 作者单位

    China CDC Natl Ctr AIDS STD Control &

    Prevent 155 Changbai Rd Beijing 102206 Peoples R China;

    China CDC Natl Ctr AIDS STD Control &

    Prevent 155 Changbai Rd Beijing 102206 Peoples R China;

    China CDC Natl Ctr AIDS STD Control &

    Prevent 155 Changbai Rd Beijing 102206 Peoples R China;

    China CDC Natl Ctr AIDS STD Control &

    Prevent 155 Changbai Rd Beijing 102206 Peoples R China;

    Beijing Ctr Dis Control &

    Prevent Beijing Peoples R China;

    Beijing Ctr Dis Control &

    Prevent Beijing Peoples R China;

    China CDC Natl Ctr AIDS STD Control &

    Prevent 155 Changbai Rd Beijing 102206 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 传染病;
  • 关键词

    acute infection; DBS; men who have sex with men; nucleic acid detection;

    机译：急性感染;DBS;与男性发生性关系;核酸检测;

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