...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>AIDS Research and Human Retroviruses >HIV-1 Subtype Diversity Based on Envelope C2V3 Sequences from Kenyan Patients on Highly Active Antiretroviral Therapy
【24h】

HIV-1 Subtype Diversity Based on Envelope C2V3 Sequences from Kenyan Patients on Highly Active Antiretroviral Therapy

机译：基于肯尼亚患者对高活性抗逆转录病毒治疗的封装C2V3序列的HIV-1亚型多样性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

There is a continuous need to genetically characterize the HIV strains in circulation in order to assess interventions and inform vaccine discovery. We partially sequenced the envelope C2V3 gene from a total of 59 Kenyan patients on highly active antiretroviral treatment (HAART) and determined HIV subtypes using both the JPHMM subtyping tool and the phylogenetic method. HIV-1 subtype A1 was the predominant strain in circulation, representing 65.5% and 74.5% of all isolates as determined by JPHMM and phylogenetic methods, respectively. Subtypes C and D were the next most prevalent pure strains at 9.1% each by both methods. JPHMM identified 9.1% of the isolates as recombinant. Four isolates had short sequences not covering the entire C2V3 region and were thus not subtyped. From this study, subtype A viruses are still the predominant HIV-1 strains in local circulation in Kenya. Constant surveillance is needed to update molecular trends under continuing HAART scale-up.
机译：循环中持续需要遗传表征HIV菌株，以评估干预措施并告知疫苗发现。 我们通过JPHMM亚型工具和系统发育方法，从总共59例肯尼昂患者组分从总共59例肯尼昂患者中排序到总共59名肯尼亚患者。 HIV-1亚型A1是循环中的主要菌株，分别由JPHMM和系统发育方法测定的所有分离株的65.5％和74.5％。 亚型C和D通过两种方法均为9.1％的下一个最普遍的纯菌株。 JPHMM将9.1％的分离株作为重组鉴定为重组。 四个分离株的短序列未覆盖整个C2v3区域，因此不是亚级。 从本研究中，病毒仍然是肯尼亚局部循环中的主要HIV-1菌株。 需要恒定监测来更新持续HAART Scale-Up下的分子趋势。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号