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首页> 外文期刊>AIDS Research and Human Retroviruses >Association Between Frailty and HIV-Associated Neurodegenerative Disorders Among Older Adults Living with HIV
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Association Between Frailty and HIV-Associated Neurodegenerative Disorders Among Older Adults Living with HIV

机译：艾滋病病毒患者的老年人之间的脆弱和艾滋病毒相关神经退行性疾病的关联

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The population of aging adults living with human immunodeficiency virus (HIV) is growing worldwide and evidence suggests that frailty occurs prematurely among them. In turn, frailty has been associated with cognitive decline. It is unknown, however, if people with both frailty and HIV infection have a higher risk of cognitive impairment compared with nonfrail HIV-infected persons. Therefore, the main objective of this study was to determine the association between the phenotype of frailty and HIV-associated neurocognitive disorders (HAND) among adults aged 50 years or older living with HIV/AIDS. A cross-sectional study was conducted on 206 adults living with HIV receiving care in a university-affiliated tertiary care hospital in Mexico City. Frailty was defined as per the Fried criteria. The presence of HAND was established according to the Antinori criteria: HIV-associated asymptomatic neurocognitive impairment (ANI), HIV-associated mild neurocognitive disorder (MND), or cognitively nonimpaired. Multinomial logistic regression models were used to test the independent association between frailty and HAND adjusting for potential confounders. Mean age of participants was 60.5 +/- 6.3 years and 84.9% were male. Prevalence of HAND and frailty phenotype was 66.0% and 2.9%, respectively. The unadjusted analysis showed that both prefrail and frail statuses were associated with MND but not with ANI. However, after adjustment, the association with MND remained significant only among prefrail participants and no longer for frail persons (risk ratio [RR] = 5.7, 95% confidence intervals [CI] 1.09-29.82; p = .039 and RR = 18.3, 95% CI 0.93-362.6; p = .056, respectively). Prefrailty is associated with symptomatic neurocognitive disorders in older adults living with HIV. The spectrum of the frailty phenotype in this already vulnerable population should serve as an indicator of concomitant cognitive decline.
机译：患有人类免疫缺陷病毒（艾滋病毒）的老化成年人人口在全球范围内越来越大，证据表明脆弱的是在他们中过早发生。反过来，脆弱已经与认知下降有关。然而，如果患有脆弱和艾滋病毒感染的人对非携带艾滋病毒感染者相比，患有脆弱和艾滋病毒感染的人具有更高的认知障碍风险。因此，本研究的主要目的是确定艾滋病毒/艾滋病50岁或以上成人的成年人的脆弱和艾滋病毒相关神经认知障碍（手）的表型之间的关联。在墨西哥城的大学附属的第三节护理医院患有艾滋病毒接受护理的206名成年人进行了横断面研究。脆弱是根据油炸标准定义的。根据Antinori标准建立了手的存在：HIV相关的无症状神经过度障碍（ANI），艾滋病毒相关的轻度神经认知疾病（MND），或认知不用。多项式物流回归模型用于测试潜在混淆的脆弱和手动调整之间的独立关联。参与者的平均年龄为60.5 +/- 6.3岁，84.9％是男性。手中的患病率和脆弱的表型分别为66.0％和2.9％。未经调整的分析表明，预制和虚线状态都与MND相关但不与ANI相关联。然而，在调整后，与MND的关联只有在预制参与者中仍有重要意义，不再适用于虚弱人员（风险比[RR] = 5.7,95％置信区间[CI] 1.09-29.82; P = .039和RR = 18.3， 95％CI 0.93-362.6; P = .056）分别）。预制与艾滋病毒患者的老年人的症状神经认知障碍有关。这种已经易受伤害的人群中脆弱表型的光谱应作为伴随认知下降的指标。

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