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首页> 外文期刊>AIDS Research and Human Retroviruses >Genomic Characterization of a Novel HIV-1 Second-Generation Recombinant Form (CRF01_AE/B) from Men Who Have Sex with Men in Guangxi Zhuang Autonomous Region, China
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Genomic Characterization of a Novel HIV-1 Second-Generation Recombinant Form (CRF01_AE/B) from Men Who Have Sex with Men in Guangxi Zhuang Autonomous Region, China

机译：来自中国广西庄庄自治区发生性关系的男性的新型HIV-1第二代重组形式（CRF01_AE / B）的基因组特征

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摘要

We report here a novel HIV-1 recombinant form (18GXD4705) composed of CRF01_AE and subtype B, acquired from an unmarried HIV-positive young man subject infected through homosexual contact in Guangxi Province of eastern China. The phylogenetic analysis of the near full-length genome of 18GXD4705 indicated that one subtype B segment was inserted into the CRF01_AE backbone, with one recombinant breakpoint demonstrated in the pol region. The CRF01_AE region (I and III) of recombinant correlated with a previously reported subcluster 4 lineage. The B subregions (II) are greatly clustered together, with B strain references. The continued generation of this novel recombinant increases the genetic complexity and diversity of the HIV epidemic in Guangxi. In addition, further molecular epidemiological investigations should be conducted to continuously monitor the dynamic transmission of HIV-1 in the region.
机译：我们在此报告一种新的HIV-1重组形式（18GxD4705）由CRF01_AE和亚型B组成，从中国广西省广西省的同性恋接触感染未婚艾滋病毒阳性的年轻人受试者获得。 18GXD4705近全长基因组的系统发育分析表明，将一个亚型B区段插入CRF01_AE骨架中，并在POL区域中证明了一种重组断裂点。 重组的CRF01_AE区域（I和III）与先前报道的子簇4谱系相关。 B个子区域（II）大大聚集在一起，B株引用。 这种新型重组的持续产生增加了广西艾滋病病毒疫情的遗传复杂性和多样性。 此外，还应进行进一步的分子流行病学调查以连续监测该地区HIV-1的动态传播。

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  • 作者

    Li Kang; Liu Meiliang; Li Jianjun; Dong Aaobo; Zhou Yuxi; Ding Yibo; Liang Yanling; Shao Yiming;

  • 作者单位

    Guangxi Med Univ Sch Publ Hlth Guangxi Key Lab Aids Prevent &

    Treatment Nanning Peoples R China;

    Guangxi Med Univ Sch Publ Hlth Guangxi Key Lab Aids Prevent &

    Treatment Nanning Peoples R China;

    Guangxi Ctr Dis Prevent &

    Control Nanning Peoples R China;

    Chinese Ctr Dis Control &

    Prevent Natl Ctr AIDS STD Control &

    Prevent State Key Lab Infect Dis;

    Guangxi Med Univ Sch Publ Hlth Guangxi Key Lab Aids Prevent &

    Treatment Nanning Peoples R China;

    Chinese Ctr Dis Control &

    Prevent Natl Ctr AIDS STD Control &

    Prevent State Key Lab Infect Dis;

    Guangxi Med Univ Sch Publ Hlth Guangxi Key Lab Aids Prevent &

    Treatment Nanning Peoples R China;

    Guangxi Med Univ Sch Publ Hlth Guangxi Key Lab Aids Prevent &

    Treatment Nanning Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 传染病;
  • 关键词

    HIV-1; recombinant; CRF01_AE; B; MSM; Guangxi; China;

    机译：HIV-1;recombinant;CRF01_AE;B;ms M;GU案G系;China;

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