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首页> 外文期刊>Acta pharmaceutica: a quarterly journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, dealing with all branches of pharmacy and allied sciences >In vitro dissolution and in vivo gamma scintigraphic evaluation of press-coated salbutamol sulfate tablets.
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In vitro dissolution and in vivo gamma scintigraphic evaluation of press-coated salbutamol sulfate tablets.

机译：压制硫酸沙丁胺醇片的体外溶出度和体内γ闪烁显像评估。

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摘要

The aim of this study was to investigate the in vitro and in vivo performance of salbutamol sulfate press-coated tablets for delayed release. The in vitro release behavior of press-coated tablets with the outer layer of PEG 6000/ Eudragit S100 blends (2:1) in pH 1.2 (0.1 mol L-1 HCl) and then pH 6.8 buffer solution was examined. Morphological change of the press-coated tablet during in vitro release was recorded with a digital camera. Release of salbutamol sulfate from press-coated tablets was less than 5 % before 3 h and was completed after 8 h in pH 6.8 phosphate buffer solution. In vivo gamma scintigraphy study carried out on healthy men indicated that the designed system released the drug in lower parts of the GI tract after a lag time of 5 hours. The results showed the capability of the system of achieving delayed release of the drug in both in vitro and in vivo gamma scintigraphy studies.
机译：这项研究的目的是研究硫酸沙丁胺醇压制片剂延迟释放的体外和体内性能。研究了PEG 6000 / Eudragit S100共混物外层（2：1）在pH 1.2（0.1 mol L-1 HCl）和pH 6.8缓冲溶液中的压制片剂的体外释放行为。用数码相机记录在体外释放过程中压制包衣片剂的形态变化。压制片剂中硫酸沙丁胺醇的释放在3小时之前少于5％，并在pH 6.8磷酸盐缓冲溶液中8小时后完全释放。对健康男性进行的体内伽玛闪烁显像研究表明，所设计的系统在滞后5小时后在胃肠道下部释放了该药物。结果显示了该系统在体外和体内γ闪烁显像研究中均能实现药物延迟释放的能力。

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