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首页> 外文期刊>Alcohol >Absence of compulsive drinking phenotype in adult male rats exposed to ethanol in a binge-like pattern during adolescence
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Absence of compulsive drinking phenotype in adult male rats exposed to ethanol in a binge-like pattern during adolescence

机译：在青春期期间在泪水状的样式暴露于乙醇的成年雄性大鼠中没有强迫饮酒表型

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The abuse of alcohol during adolescence is widespread and represents a particular concern, given that earlier age of drinking onset is associated with increased risk for the development of alcohol use disorders (AUDs). Despite this risk, it remains unclear whether binge-like adolescent alcohol exposure facilitates drinking despite aversive consequences, a characteristic common among individuals with AUDs. The present study examined voluntary alcohol consumption and aversion-resistant drinking in adult male Long-Evans rats that had undergone adolescent intermittent ethanol (AIE) exposure by vapor inhalation between postnatal days (PD) 28-44. Ethanol consumption during adulthood was examined using a two-bottle choice (2BC) intermittent access procedure. Rats were tested for aversion-resistant drinking using ethanol adulterated with quinine (10, 30, 100 mg/L) after two 7-week periods of 2BC drinking. After completion of the second test of aversion-resistant drinking, rats were trained to operantly self-administer ethanol. The results revealed that both air control (AIR) and AIE-exposed rats exhibited similar ethanol intake and preference in the 2BC paradigm. After 7 weeks of 2BC drinking, quinine adulteration significantly suppressed ethanol intake, but only at the highest concentration examined (100 mg/L). However, upon retesting after a total of 17 weeks of 2BC drinking, 30-mg/L quinine suppressed ethanol intake. Notably, AIR- and AIE-exposed rats were equally sensitive to quinine adulterated ethanol at both time points. In addition, AIR- and AIE-exposed rats responded similarly during operant ethanol self-administration on both fixed and progressive ratio schedules of reinforcement. Finally, both AIR- and AIE-exposed rats exhibited similar preference for sucrose. The results of this study show that binge-like ethanol vapor exposure during adolescence does not alter voluntary ethanol consumption, motivation to operantly respond for ethanol, or promote aversion-resistant ethanol consumption in adulthood. These data, together with previous work reporting conflicting results across various rodent models of adolescent alcohol exposure, underscore the need to further explore the role that exposure to alcohol during adolescence has on the development of heavy and compulsive drinking phenotypes in adulthood. (C) 2019 Elsevier Inc. All rights reserved.
机译：鉴于早期饮酒年龄与饮酒障碍的风险增加有关的情况下，青春期滥用酒精是普遍的并且代表了特定的问题。尽管存在这种风险，但仍然尚不清楚狂犬病的青少年酒精曝光是否有助于饮酒，尽管厌恶后果，具有澳元的个人的特征。本研究检测了在后期（Pd）28-44之间经过青少年间歇性乙醇（AIE）暴露的成年男性长凡凡大鼠的自愿饮酒和厌恶饮用。使用双瓶选择（2BC）间歇性接入程序检查成年期间的乙醇消耗。在2BC饮用的两次7周期后，使用乙醇掺杂含有奎宁（10,30,100mg / L）的乙醇测试厌恶饮用的大鼠。在完成耐脂性饮用饮酒的第二次测试后，培训大鼠以常识乙醇。结果表明，空气管道（空气）和艾米曝光大鼠在2BC范例中表现出类似的乙醇摄入和偏好。 2BC饮用7周后，奎宁掺假显着抑制乙醇的摄入，但仅在浓度最高（100 mg / L）。但是，在重新测试后，在共17周的2BC饮用后，30-Mg / L奎宁抑制乙醇摄入量。值得注意的是，空气和曝光的大鼠对两次纯掺杂的乙醇同等敏感。此外，在固定和渐进式比例调度的操作型乙醇自我管理期间，空气和AIE暴露的大鼠同样反应。最后，空气和曝光的大鼠都表现出类似的蔗糖的偏好。该研究的结果表明，白炽般的乙醇蒸气暴露不会改变自愿乙醇消耗，乙醇响应的动机，或促进成年期耐逆转乙醇消耗。这些数据以及以前的工作报告了各种啮齿动物曝光的啮齿动物模型的冲突结果，强调了进一步探索青春期期间暴露于酒精的作用的必要性对成年期的重型和强迫饮酒表型开发。 （c）2019 Elsevier Inc.保留所有权利。

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