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The contributions of Dr. Kathleen K. Sulik to fetal alcohol spectrum disorders research and prevention

机译：Kathleen K. Sulik博士对胎儿酒精谱紊乱的贡献研究和预防

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Dr. Kathleen Sulik (Kathy) has spent 35 years studying fetal alcohol syndrome (FAS) and fetal alcohol spectrum disorders (FASD). Beginning with her landmark 1981Sciencepaper describing the early gestational window when alcohol can cause the craniofacial malformations characteristic of FAS, Kathy has contributed a vast amount of research furthering our knowledge of FASD. After her seminal work that definitively demonstrated that alcohol is the causative factor in FAS, she and her lab went on to explore and define the stage-dependent effects of early gestational alcohol exposure on the face and brain in numerous different ways throughout her career. She explored and discovered numerous mechanisms of alcohol's effects on the embryo, as well as describing several genetic factors that can modify susceptibility to developmental alcohol exposure. She did not restrict her research to the face and brain; her lab described in intricate detail the effects of developmental alcohol exposure on many different organs, including the heart, ears, kidneys, and limbs. In addition to her research, and in conjunction with NIAAA and the National Organization on Fetal Alcohol Syndrome (NOFAS), Kathy developed several FASD prevention curricula that are still in use today. Finally, as part of her drive to eradicate FAS and FASD, Kathy labored tirelessly with public policy makers to change how FASD is viewed by the public, how FASD is identified in affected individuals, and how FASD is studied by researchers. While no article could fully cover Kathy's contributions to FASD research and prevention, or her other contributions to embryology and teratology, this review will attempt to illustrate some of the highlights of Kathy's remarkable career.
机译：Kathleen Sulik博士（凯西）已经花了35年的学习胎醇综合征（FAS）和胎儿酒精谱紊乱（FASD）。从她的地标1981cience纸片开始描述早期的孕窗，当酒精会导致Fas的颅面畸形特征时，凯西贡献了大量的研究进一步推动了我们对FASD的了解。在她的精美工作明确证明酒精是Fas的致病因素，她和她的实验室继续探索并定义早期妊娠酒精暴露在整个职业生涯中众多不同方式的早期妊娠酒精暴露的阶段依赖作用。她探索并发现了许多酒精对胚胎作用的机制，以及描述了可以改变发育酒精暴露易感性的几种遗传因素。她没有将她的研究限制在面部和大脑上;她的实验室描述了复杂的细节发育酒精暴露对许多不同器官的影响，包括心脏，耳朵，肾脏和四肢。除了她的研究外，还与NIAAA和国家胎儿酒精综合征（Nofas）结合使用，Kathy开发了今天仍在使用的FASD预防课程。最后，作为她开车的一部分，因为她的驱逐FAS和FASD，Kathy与公共政策制定者更加不知疲倦地努力改变公众观看FASD的方式，如何在受影响的个人中确定FASD以及研究人员如何研究FASD。虽然没有文章可以充分涵盖凯西对FASD研究和预防的贡献，或者她对胚胎学和Teratology的其他贡献，但这条评论将试图说明凯西的一些亮点的卓越职业生涯。

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