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首页> 外文期刊>Alcohol >Alignment of the transcriptome with individual variation in animals selectively bred for High Drinking-In-the-Dark (HDID)
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Alignment of the transcriptome with individual variation in animals selectively bred for High Drinking-In-the-Dark (HDID)

机译：转录组与单独的动物的变异对准，选择性地培育高饮酒 - 内 - 黑暗（HDID）

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Among animals at risk for excessive ethanol consumption such as the HDID selected mouse lines, there is considerable individual variation in the amount of ethanol consumed and the associated blood ethanol concentrations (BECs). For the HDID lines, this variation occurs even though the residual genetic variation associated with the DID phenotype has been largely exhausted and thus is most likely associated with epigenetic factors. Here we focus on the question of whether the genes associated with individual variation in HDID-1 mice are different from those associated with selection (risk) (Iancu et al., 2013). Thirty-three HDID-1 mice were phenotyped for their BECs at the end of a standard DID trial, were sacrificed 3 weeks later, and RNA-Seq was used to analyze the striatal transcriptome. The data obtained illustrate that there is considerable overlap of the risk and variation gene sets, both focused on the fine-tuning of synaptic plasticity. (C) 2017 Elsevier Inc. All rights reserved.
机译：在诸如HDID选定的小鼠线的过量乙醇消耗的风险中的动物中，消耗的乙醇的量和相关的血液乙醇浓度（BECS）存在相当大的单独变化。 对于HDID线，即使与DID表型相关的残留遗传变异已经大大耗尽，因此也很可能与表观遗传因素有关。 在这里，我们专注于与HDID-1小鼠的个体变异相关的基因的问题与选择（风险）相关的基因（风险）（Iancu等，2013）。 在标准试验结束时，三十三个HDID-1小鼠对其BECS进行了表型，3周后处死，并且RNA-SEQ用于分析纹状体转录组。 所获得的数据说明风险和变异基因集的相当大的重叠，既集中于突触塑性的微调。 （c）2017年Elsevier Inc.保留所有权利。

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